PMID- 8491507
OWN - NLM
STAT- MEDLINE
DCOM- 19930611
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 21
IP  - 5
DP  - 1993 May
TI  - Sodium retention and hypertension after kidney transplantation in rats.
PG  - 724-30
AB  - The present study was designed to investigate the development of blood pressure 
      and renal sodium handling in recipients of renal grafts from adult stroke-prone 
      spontaneously hypertensive rats (SHRSP), normotensive Wistar-Kyoto (WKY) rats, 
      and borderline hypertensive F1 hybrids bred from SHRSP and WKY rats. Unilaterally 
      nephrectomized F1 hybrids served as renal graft recipients. The second native 
      kidney was removed 7 days after transplantation. Starting on the day of 
      transplantation, renal graft recipients were put on a standard diet for 7 days 
      followed by a low salt diet (0.18% salt) for 10 days and a high salt diet (1.8% 
      salt) for another 14 days. In recipients of a renal graft from SHRSP donors, 
      systolic blood pressure rose progressively from 140 +/- 4 mm Hg before to 190 +/- 
      7 mm Hg 4 weeks after transplantation. In contrast, in recipients of a renal 
      graft from WKY rat donors, blood pressure fell during the same time from 139 +/- 
      7 mm Hg to 120 +/- 4 mm Hg. Blood pressure did not change significantly in 
      recipients of a renal graft from F1 hybrid donors (132 +/- 4 versus 138 +/- 7 mm 
      Hg). With transition from a low salt to high salt diet, all rats exhibited renal 
      sodium retention. The accumulating amount of sodium retained by the renal graft 
      was significantly higher in recipients of an SHRSP kidney than in recipients of a 
      WKY rat kidney at all days on the high salt diet.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Graf, C
AU  - Graf C
AD  - Department of Pharmacology, University of Heidelberg, FRG.
FAU - Maser-Gluth, C
AU  - Maser-Gluth C
FAU - de Muinck Keizer, W
AU  - de Muinck Keizer W
FAU - Rettig, R
AU  - Rettig R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Aldosterone/urine
MH  - Animals
MH  - Blood Pressure
MH  - Body Weight
MH  - Cerebrovascular Disorders
MH  - Diet
MH  - Hypertension/*etiology/metabolism
MH  - *Kidney Transplantation
MH  - Male
MH  - Natriuresis
MH  - Postoperative Complications
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Sodium/*metabolism
MH  - Sodium Chloride/administration & dosage
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1161/01.hyp.21.5.724 [doi]
PST - ppublish
SO  - Hypertension. 1993 May;21(5):724-30. doi: 10.1161/01.hyp.21.5.724.