PMID- 8494046
OWN - NLM
STAT- MEDLINE
DCOM- 19930614
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 142
IP  - 5
DP  - 1993 May
TI  - Enhanced production of the chemotactic cytokines interleukin-8 and monocyte 
      chemoattractant protein-1 in human abdominal aortic aneurysms.
PG  - 1423-31
AB  - Inflammatory leukocytes play a central role in the pathogenesis of human 
      atherosclerotic disease, from early atherogenesis to the late stages of 
      atherosclerosis, such as aneurysm formation. We have shown previously that human 
      abdominal aortic aneurysms are characterized by the presence of numerous chronic 
      inflammatory cells throughout the vessel wall (Am J Pathol 1990, 137: 1199-1213). 
      The signals that attract lymphocytes and monocytes into the aortic wall in 
      aneurysmal disease remain to be precisely defined. We have studied the production 
      of the chemotactic cytokines interleukin-8 (IL-8) and monocyte chemoattractant 
      protein-1 (MCP-1) by aortic tissues obtained from 47 subjects. We compared the 
      antigenic production of these cytokines by explants of: 1) human abdominal 
      aneurysmal tissue, 2) occlusive (atherosclerotic) aortas, and 3) normal aortas. 
      IL-8, which is chemotactic for neutrophils, lymphocytes, and endothelial cells 
      was liberated in greater quantities by abdominal aortic aneurysms than by 
      occlusive or normal aortas. Using immunohistochemistry, macrophages, and to a 
      lesser degree endothelial cells, were found to be positive for the expression of 
      antigenic IL-8. Similarly, MCP-1, a potent chemotactic cytokine for 
      monocytes/macrophages, was released by explants from abdominal aortic aneurysms 
      in greater quantities than by explants from occlusive or normal aortas. Using 
      immunohistochemistry, the predominant MCP-1 antigen-positive cells were 
      macrophages and to a lesser extent smooth muscle cells. Our results indicate that 
      human abdominal aortic aneurysms produce IL-8 and MCP-1, both of which may serve 
      to recruit additional inflammatory cells into the abdominal aortic wall, hence 
      perpetuating the inflammatory reaction that may result in the pathology of vessel 
      wall destruction and aortic aneurysm formation.
FAU - Koch, A E
AU  - Koch AE
AD  - Department of Medicine, Northwestern University Medical School, Chicago, IL 
      60611.
FAU - Kunkel, S L
AU  - Kunkel SL
FAU - Pearce, W H
AU  - Pearce WH
FAU - Shah, M R
AU  - Shah MR
FAU - Parikh, D
AU  - Parikh D
FAU - Evanoff, H L
AU  - Evanoff HL
FAU - Haines, G K
AU  - Haines GK
FAU - Burdick, M D
AU  - Burdick MD
FAU - Strieter, R M
AU  - Strieter RM
LA  - eng
GR  - AR30692/AR/NIAMS NIH HHS/United States
GR  - AR41492/AR/NIAMS NIH HHS/United States
GR  - HL02401/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Aortic Aneurysm, Abdominal/*metabolism/pathology
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*biosynthesis
MH  - Chemotaxis/physiology
MH  - Cytokines/*biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-8/*biosynthesis
PMC - PMC1886921
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
PMCR- 1993/11/01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
PHST- 1993/11/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1993 May;142(5):1423-31.