PMID- 8495229
OWN - NLM
STAT- MEDLINE
DCOM- 19930622
LR  - 20131121
IS  - 1065-6995 (Print)
IS  - 1065-6995 (Linking)
VI  - 17
IP  - 1
DP  - 1993 Jan
TI  - Stimulation of DNA synthesis in skin fibroblasts by human hepatocyte growth 
      factor/scatter factor.
PG  - 65-73
AB  - The effect of hepatocyte growth factor/scatter factor (HGF/SF) on the 
      proliferation of human skin fibroblasts was examined. At concentrations above 1.0 
      ng/ml, both native and recombinant human HGF/SF stimulated the DNA synthesis 
      determined by [3H]thymidine incorporation, which was completely inhibited by an 
      anti-human HGF/SF monoclonal antibody. The maximal DNA synthesis in the treated 
      cells was nearly twice that in untreated cells. HGF/SF also caused an increase in 
      the labelling index, DNA content and cell number. The effect of HGF/SF was more 
      than additive to the maximal effect of insulin and epidermal growth factor, other 
      mitogens for the fibroblasts. These results indicate that human skin fibroblasts 
      are sensitive to the mitogenic action of HGF/SF.
FAU - Kataoka, H
AU  - Kataoka H
AD  - Department of Immunocytochemistry, Faculty of Pharmaceutical Sciences, Okayama 
      University, Japan.
FAU - Gohda, E
AU  - Gohda E
FAU - Matsunaga, T
AU  - Matsunaga T
FAU - Ishii, T
AU  - Ishii T
FAU - Hara, H
AU  - Hara H
FAU - Yamamoto, I
AU  - Yamamoto I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Recombinant Proteins)
RN  - 10028-17-8 (Tritium)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-49-2 (DNA)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Antibodies, Monoclonal/immunology/pharmacology
MH  - Cell Count/drug effects
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Child
MH  - DNA/analysis/*biosynthesis
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fibroblasts/chemistry/cytology/*metabolism
MH  - Hepatocyte Growth Factor/immunology/*pharmacology
MH  - Humans
MH  - Recombinant Proteins/pharmacology
MH  - Skin/*cytology
MH  - Thymidine/metabolism
MH  - Tritium
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - S1065-6995(83)71006-1 [pii]
AID - 10.1006/cbir.1993.1006 [doi]
PST - ppublish
SO  - Cell Biol Int. 1993 Jan;17(1):65-73. doi: 10.1006/cbir.1993.1006.