PMID- 8498307
OWN - NLM
STAT- MEDLINE
DCOM- 19930621
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 125
IP  - 6
DP  - 1993 Jun
TI  - Effects of intravenous magnesium sulfate on arrhythmias in patients with 
      congestive heart failure.
PG  - 1645-50
AB  - Intravenous magnesium is an effective treatment for ventricular tachycardia of 
      some etiologies, and in patients with congestive heart failure low serum 
      magnesium concentrations are associated with frequent arrhythmias and high 
      mortality. This suggests that magnesium administration may decrease the frequency 
      of ventricular arrhythmias in patients with heart failure. We therefore assessed 
      the impact of an intravenous magnesium infusion upon the frequency of ventricular 
      premature depolarizations in 40 patients with New York Heart Association (NYHA) 
      class II to IV heart failure and serum magnesium < or = 2.0 mg/dl. Within 1 week 
      of a baseline 6-hour ambulatory electrocardiographic recording, an infusion of 
      0.2 mEq/kg of MgSO4 was given over 1 hour and a repeat 6-hour recording was 
      obtained. There was an inverse relationship between the change in magnesium 
      concentration and the change in frequency of premature ventricular 
      depolarizations; premature ventricular depolarizations declined by 134 +/- 207 
      hr-1 in patients in whom serum magnesium concentration increased > or = 0.75 
      mg/dl, but increased by 72 +/- 393 hr-1 in patients with a change < 0.75 mg/dl (p 
      < 0.05). For all patients, the frequency of premature ventricular depolarizations 
      was 283 +/- 340 hr-1 pretreatment and 220 +/- 269 hr-1 following magnesium 
      infusion (p = 0.21). Patients with > or = 300 premature ventricular 
      depolarizations hr-1 demonstrated a decrease from 794 +/- 309 to 369 +/- 223 hr-1 
      (p < 0.001). Intravenous magnesium administration decreased the frequency of 
      couplets from 233 +/- 505 to 84 +/- 140 (p < 0.05).(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Gottlieb, S S
AU  - Gottlieb SS
AD  - Division of Cardiology, University of Maryland School of Medicine, Baltimore 
      21201.
FAU - Fisher, M L
AU  - Fisher ML
FAU - Pressel, M D
AU  - Pressel MD
FAU - Patten, R D
AU  - Patten RD
FAU - Weinberg, M
AU  - Weinberg M
FAU - Greenberg, N
AU  - Greenberg N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 7487-88-9 (Magnesium Sulfate)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/blood/*drug therapy/physiopathology
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - *Heart Failure/blood/physiopathology
MH  - Humans
MH  - Infusions, Intravenous
MH  - Magnesium/blood
MH  - Magnesium Sulfate/administration & dosage/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 0002-8703(93)90754-W [pii]
AID - 10.1016/0002-8703(93)90754-w [doi]
PST - ppublish
SO  - Am Heart J. 1993 Jun;125(6):1645-50. doi: 10.1016/0002-8703(93)90754-w.