PMID- 8501339
OWN - NLM
STAT- MEDLINE
DCOM- 19930629
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 167
IP  - 6
DP  - 1993 Jun
TI  - Involvement of interferon-gamma and tumor necrosis factor-alpha in host defense 
      against Rhodococcus equi.
PG  - 1456-9
AB  - Rhodococcus equi is a facultative, intracellular, gram-positive coccobacillus 
      increasingly reported as an opportunistic pathogen in AIDS patients. In vitro, 
      splenic cells of noninfected euthymic mice produced tumor necrosis factor-alpha 
      (TNF alpha) in greater amounts when incubated with live R. equi rather than with 
      killed bacteria. In vivo, interferon-gamma (IFN-gamma) and TNF alpha serum levels 
      of infected euthymic mice remained below the level of detectability. Treatment of 
      infected nude mice, which developed chronic infection, with discontinuous 
      injections of IFN-gamma, TNF alpha, or both did not decrease bacterial 
      colony-forming units in liver, spleen, or lungs. However, treatment of infected 
      euthymic mice, which cured a R. equi inoculum within 3 weeks, with anti-IFN-gamma 
      or anti-TNF alpha antibodies (or both) significantly increased tissue colony 
      counts. These data argue that, in this murine model, endogenous IFN-gamma and TNF 
      alpha are involved in the cell-mediated immunologic response against R. equi 
      infection.
FAU - Nordmann, P
AU  - Nordmann P
AD  - Department of Microbiology, Paris-Ouest Medical School, Paris V University, 
      Garches, France.
FAU - Ronco, E
AU  - Ronco E
FAU - Guenounou, M
AU  - Guenounou M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Actinomycetales Infections/*immunology
MH  - Animals
MH  - Female
MH  - Interferon-gamma/*immunology
MH  - Mice
MH  - Mice, Nude
MH  - Rhodococcus equi/*immunology
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1093/infdis/167.6.1456 [doi]
PST - ppublish
SO  - J Infect Dis. 1993 Jun;167(6):1456-9. doi: 10.1093/infdis/167.6.1456.