PMID- 8501522
OWN - NLM
STAT- MEDLINE
DCOM- 19930628
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 13
IP  - 6
DP  - 1993 Jun
TI  - Delayed pattern discrimination in patients with unilateral temporal lobe damage.
PG  - 2565-74
AB  - Behavioral and neurophysiological studies in macaque monkeys suggest a role of 
      the inferior temporal cortex in pattern discrimination and visual memory. To 
      determine whether this cortical area is also involved in human short-term visual 
      memory, we measured spatial frequency discrimination thresholds for sequentially 
      presented stimuli in 17 patients with unilateral, postoperative focal damage to 
      the temporal cortex (11 left, 6 right hemisphere). These results are compared to 
      those of 17 age-matched control subjects. Contrast detection thresholds and 
      difference thresholds for spatial frequency were determined for spatially 
      truncated sine wave gratings presented in the left and right visual fields. 
      Detection thresholds were measured for sine wave gratings in a spatial 
      two-alternative forced-choice procedure for three spatial frequencies [2.5, 5, 
      and 10 cycles (c)/degree] for each hemifield. Discrimination thresholds were 
      determined for two gratings sequentially presented either 4 degrees to the left 
      or right of fixation. Grating contrast was five times the value of detection 
      threshold and reference frequency was 5 c/degree. Within each trial, the gratings 
      were separated in time by 1, 3, and 10 sec interstimulus intervals (ISIs), and 
      subjects signaled which grating had the higher spatial frequency. The results 
      indicate that (1) contrast detection thresholds overall did not differ between 
      patient and control groups; (2) spatial frequency discrimination thresholds were, 
      however, significantly elevated in patients and this elevation was significantly 
      more pronounced in the visual field contralateral to the damaged hemisphere; and 
      (3) patients with inferotemporal damage exhibited higher discrimination 
      thresholds for the longest ISI, whereas patients with medial/superior temporal 
      lobe damage did not show this effect. The results suggest that visual areas in 
      human temporal cortex are involved in the higher visual processes underlying 
      delayed pattern discrimination.
FAU - Greenlee, M W
AU  - Greenlee MW
AD  - Neurologische Universitatsklinik, Freiburg, Germany.
FAU - Rischewski, J
AU  - Rischewski J
FAU - Mergner, T
AU  - Mergner T
FAU - Seeger, W
AU  - Seeger W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - Aging/physiology
MH  - Analysis of Variance
MH  - Brain Diseases/diagnostic imaging/*physiopathology/psychology
MH  - Contrast Sensitivity
MH  - Differential Threshold
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pattern Recognition, Visual
MH  - Psychophysics/methods
MH  - Reaction Time
MH  - *Temporal Lobe
MH  - Tomography, X-Ray Computed
PMC - PMC6576501
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
PMCR- 1993/12/01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
PHST- 1993/12/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.13-06-02565.1993 [doi]
PST - ppublish
SO  - J Neurosci. 1993 Jun;13(6):2565-74. doi: 10.1523/JNEUROSCI.13-06-02565.1993.