PMID- 8506116
OWN - NLM
STAT- MEDLINE
DCOM- 19930708
LR  - 20220227
IS  - 0141-9838 (Print)
IS  - 0141-9838 (Linking)
VI  - 15
IP  - 4
DP  - 1993 Apr
TI  - Protective immunity and mast cell and eosinophil responses in mice infested with 
      larval Haemaphysalis longicornis ticks.
PG  - 209-14
AB  - WBB6F1-+/+ mice were infested with larval Haemaphysalis longicornis ticks twice 
      at an interval of 14 days: apparent resistance against ticks was expressed in the 
      second infestation. The first infestation induced degranulation of a small number 
      of mast cells at the feeding sites within 6 days, and resulted in two-fold 
      increases of mast cell numbers on day 14 with a significant elevation of total 
      immunoglobulin E (IgE) levels in sera and high proportion of IgE-bound mast 
      cells. The second infestation resulted in the intensive degranulation of the 
      increased mast cells at the feeding sites. Eosinophils infiltrated into the 
      feeding sites of ticks: the second infestation led to a greater maximal level of 
      the infiltrating eosinophils. These data suggest that the resistance against 
      larval H. longicornis ticks in mice may be expressed as a result of immediate 
      hypersensitivity and many eosinophils infiltrating from the blood to the feeding 
      sites might contribute to the tick rejection.
FAU - Ushio, H
AU  - Ushio H
AD  - Department of Veterinary Surgery, College of Agriculture, University of Osaka 
      Prefecture, Japan.
FAU - Watanabe, N
AU  - Watanabe N
FAU - Kiso, Y
AU  - Kiso Y
FAU - Higuchi, S
AU  - Higuchi S
FAU - Matsuda, H
AU  - Matsuda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Cell Degranulation
MH  - Eosinophils/*immunology
MH  - Hypersensitivity, Immediate/immunology
MH  - Immunity, Active
MH  - Immunoglobulin E/biosynthesis
MH  - Larva/immunology
MH  - Leukocyte Count
MH  - Male
MH  - Mast Cells/*immunology/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/immunology
MH  - Skin/immunology/pathology
MH  - Specific Pathogen-Free Organisms
MH  - Tick Infestations/*immunology/pathology
MH  - Ticks/*immunology
MH  - Time Factors
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1111/j.1365-3024.1993.tb00602.x [doi]
PST - ppublish
SO  - Parasite Immunol. 1993 Apr;15(4):209-14. doi: 10.1111/j.1365-3024.1993.tb00602.x.