PMID- 8506226
OWN - NLM
STAT- MEDLINE
DCOM- 19930707
LR  - 20190905
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 13
IP  - 4
DP  - 1993 Apr
TI  - Rapid detection of aneuploidy in uncultured chorionic villus cells using 
      fluorescence in situ hybridization.
PG  - 233-8
AB  - Rapid detection of aneuploidy using chromosome-specific repetitive DNA probes and 
      the potential diagnostic accuracy of fluorescence in situ hybridization (FISH) on 
      interphase cells of chorionic villus samples (CVS) are presented. Analyses 
      demonstrated the ability to correctly identify aneuploidy using FISH in 
      uncultured CVS. Our preliminary investigation suggests that this technique offers 
      a significant clinical potential to circumvent problems of culture, time, and 
      cost in cytogenetic analysis.
FAU - Rao, P N
AU  - Rao PN
AD  - Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, 
      Winston-Salem, NC 27157.
FAU - Hayworth, R
AU  - Hayworth R
FAU - Cox, K
AU  - Cox K
FAU - Grass, F
AU  - Grass F
FAU - Pettenati, M J
AU  - Pettenati MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
RN  - 0 (DNA Probes)
SB  - IM
MH  - *Aneuploidy
MH  - Chorionic Villi/*ultrastructure
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Repetitive Sequences, Nucleic Acid
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1002/pd.1970130402 [doi]
PST - ppublish
SO  - Prenat Diagn. 1993 Apr;13(4):233-8. doi: 10.1002/pd.1970130402.