PMID- 8509780
OWN - NLM
STAT- MEDLINE
DCOM- 19930712
LR  - 20190501
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 56
IP  - 6
DP  - 1993 Jun
TI  - High resolution SPECT with [99mTc]-d,l-HMPAO in normal pressure hydrocephalus 
      before and after shunt operation.
PG  - 655-64
AB  - Cranial CT and high resolution measurements of regional cerebral blood flow 
      (rCBF) with brain dedicated single photon emission computer tomography (SPECT) 
      and [99mTc]-d,l-hexamethylpropyleneamine oxime ([99mTc]-d,l-HMPAO) were performed 
      before and after shunt operation in 14 consecutive patients with dementia and 
      normal pressure hydrocephalus (NPH). When compared with a control group of 14 age 
      matched healthy volunteers, the group of NPH patients was characterised by an 
      enlarged subcortical low-flow region, significantly reduced rCBF and enhanced 
      side-to-side asymmetry of rCBF in the central white matter, and enhanced 
      side-to-side asymmetry in the inferior and mid-temporal cortex. Global CBF was 
      normal. Shunt operation reduced the mean area of the ventricles on CT and of the 
      subcortical low-flow region on SPECT. Global CBF was unchanged. All 14 patients 
      had an abnormal pre-shunt rCBF pattern with enlargement of the subcortical low 
      flow region, focal cortical blood flow deficits, or both. Shunt operation 
      improved the clinical status in 11 patients, and the area of the subcortical low 
      flow region correctly classified 3/3 unimproved and 10/11 improved patients. 
      Shunt operation normalised or reduced the area of the subcortical low flow region 
      in nine of 10 patients. It is concluded that SPECT with [99mTc]-d,l-HMPAO is a 
      useful supplement in the diagnosis of NPH versus normal ageing, and that SPECT 
      may help to identify patients not likely to benefit clinically from surgery.
FAU - Waldemar, G
AU  - Waldemar G
AD  - Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
FAU - Schmidt, J F
AU  - Schmidt JF
FAU - Delecluse, F
AU  - Delecluse F
FAU - Andersen, A R
AU  - Andersen AR
FAU - Gjerris, F
AU  - Gjerris F
FAU - Paulson, O B
AU  - Paulson OB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Oximes)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*diagnostic imaging/physiopathology/surgery
MH  - *Cerebrospinal Fluid Shunts
MH  - Cerebrovascular Circulation/physiology
MH  - Female
MH  - Humans
MH  - Hydrocephalus, Normal Pressure/*diagnostic imaging/physiopathology/surgery
MH  - Male
MH  - Middle Aged
MH  - *Organotechnetium Compounds
MH  - *Oximes
MH  - Prognosis
MH  - Technetium Tc 99m Exametazime
MH  - Time Factors
MH  - Tomography, Emission-Computed, Single-Photon
PMC - PMC489616
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
PMCR- 1993/06/01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
PHST- 1993/06/01 00:00 [pmc-release]
AID - 10.1136/jnnp.56.6.655 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 1993 Jun;56(6):655-64. doi: 10.1136/jnnp.56.6.655.