PMID- 8514195 OWN - NLM STAT- MEDLINE DCOM- 19930722 LR - 20190707 IS - 0378-1119 (Print) IS - 0378-1119 (Linking) VI - 128 IP - 2 DP - 1993 Jun 30 TI - Cloning of an adenosine A1 receptor-encoding gene from rabbit. PG - 285-8 AB - A partial cDNA encoding the A1 adenosine receptor (A1AR), which lacks nucleotides coding for the first 74 amino acids (aa), was isolated from a rabbit kidney cDNA library. The missing 5' end sequence was obtained from an overlapping rabbit genomic clone which was found to contain the flanking 5' untranslated region (5'UTR), the first exon and part of the first intron. Together, the cDNA and genomic clones provide the entire open reading frame (ORF) encoding rabbit A1AR. The deduced aa sequence is highly homologous to the canine, rat and bovine A1ARs. These data also indicate that the A1AR gene belongs to the family of intron-containing G-protein-linked receptor genes. FAU - Bhattacharya, S AU - Bhattacharya S AD - Department of Physiology, Michigan State University, East Lansing 48824. FAU - Dewitt, D L AU - Dewitt DL FAU - Burnatowska-Hledin, M AU - Burnatowska-Hledin M FAU - Smith, W L AU - Smith WL FAU - Spielman, W S AU - Spielman WS LA - eng SI - GENBANK/D13301 SI - GENBANK/D13302 SI - GENBANK/L01700 SI - GENBANK/L03653 SI - GENBANK/L03654 SI - GENBANK/L07632 SI - GENBANK/L11609 SI - GENBANK/L11610 SI - GENBANK/X54209 SI - GENBANK/X67926 GR - DK 22042/DK/NIDDK NIH HHS/United States GR - DK 39654/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - Netherlands TA - Gene JT - Gene JID - 7706761 RN - 0 (DNA-Binding Proteins) RN - 0 (Receptors, Purinergic) RN - EC 3.6.1.- (GTP-Binding Proteins) RN - K72T3FS567 (Adenosine) SB - IM GS - A1AR MH - Adenosine MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Cattle MH - Cloning, Molecular MH - DNA-Binding Proteins MH - Dogs MH - GTP-Binding Proteins/*genetics MH - Introns MH - Molecular Sequence Data MH - Open Reading Frames MH - Rabbits MH - Rats MH - Receptors, Purinergic/*genetics MH - Sequence Homology, Nucleic Acid EDAT- 1993/06/30 00:00 MHDA- 1993/06/30 00:01 CRDT- 1993/06/30 00:00 PHST- 1993/06/30 00:00 [pubmed] PHST- 1993/06/30 00:01 [medline] PHST- 1993/06/30 00:00 [entrez] AID - 0378-1119(93)90576-O [pii] AID - 10.1016/0378-1119(93)90576-o [doi] PST - ppublish SO - Gene. 1993 Jun 30;128(2):285-8. doi: 10.1016/0378-1119(93)90576-o.