PMID- 8521048
OWN - NLM
STAT- MEDLINE
DCOM- 19960125
LR  - 20191023
IS  - 0266-7061 (Print)
IS  - 0266-7061 (Linking)
VI  - 11
IP  - 4
DP  - 1995 Aug
TI  - Chromosome aberrations produced by ionizing radiation: Monte Carlo simulations 
      and chromosome painting data.
PG  - 389-97
AB  - Monte Carlo simulations are used to analyze the reshuffling of chromosome 
      segments which occurs when DNA is damaged by ionizing radiation. Programs are 
      based on either Sax's classic breakage-and-reunion model or Revell's exchange 
      model for chromosome aberrations. The simulations quantify the predictions of the 
      two models in complete detail, using only one adjustable parameter which 
      corresponds to total radiation dose. While testing subroutines, new analytic 
      results on the chromosome/arm/break method of classifying aberrations were 
      obtained. The model predictions were tested by using three-color fluorescence in 
      situ hybridization (FISH) 'chromosome painting' on human lymphocyte cells 
      irradiated with gamma-rays. Some of the per-cell aberration frequencies were 
      observed to be intermediate between the predictions of the two models. This 
      result indicates proximity 'effects', due to localization of chromosome 
      interactions in space and time. Predictions based on chromosome arm lengths were 
      found to be in good agreement with experiment. Monte Carlo simulations are a 
      powerful, flexible way to compare models of chromosome aberration production with 
      experiments quantitatively, using a minimum of theoretical presumptions.
FAU - Chen, A M
AU  - Chen AM
AD  - Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.
FAU - Lucas, J N
AU  - Lucas JN
FAU - Hill, F S
AU  - Hill FS
FAU - Brenner, D J
AU  - Brenner DJ
FAU - Sachs, R K
AU  - Sachs RK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Comput Appl Biosci
JT  - Computer applications in the biosciences : CABIOS
JID - 8511758
SB  - IM
MH  - Algorithms
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human/*radiation effects/ultrastructure
MH  - *Computer Simulation
MH  - DNA Damage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Models, Genetic
MH  - *Monte Carlo Method
MH  - Software
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1093/bioinformatics/11.4.389 [doi]
PST - ppublish
SO  - Comput Appl Biosci. 1995 Aug;11(4):389-97. doi: 10.1093/bioinformatics/11.4.389.