PMID- 8521205
OWN - NLM
STAT- MEDLINE
DCOM- 19960125
LR  - 20190909
IS  - 1069-6563 (Print)
IS  - 1069-6563 (Linking)
VI  - 2
IP  - 7
DP  - 1995 Jul
TI  - Intravenous chlorpromazine vs intravenous metoclopramide in acute migraine 
      headache.
PG  - 597-602
AB  - OBJECTIVE: To compare the efficacy of IV chlorpromazine with that of IV 
      metoclopramide in the treatment for acute migraine headache in the ED. METHODS: A 
      prospective randomized double-blind trial was undertaken at two 
      university-affiliated urban EDs with a combined annual census of more than 85,000 
      patients. Included in the study were patients presenting to the ED with a 
      diagnosis of migraine headache. The subjects were randomized to receive 0.1 
      mg/kg/dose IV of either chlorpromazine (CPZ) or metoclopramide (MC), up to a 
      total of three doses. RESULTS: Ninety-one patients completed the protocol; 44 
      received MC and 47 received CPZ. The demographics of the two groups were similar. 
      Both drugs provided, for the majority of patients, adequate pain relief as 
      measured on a visual analog scale (VAS) completed every 15 minutes from T = 0 
      minutes to T = 45 minutes. The average pain relief over 45 minutes (delta VAS) 
      for CPZ was 4.87 cm, vs 4.34 cm for MC (p = 0.35). There also was no 
      statistically significant difference in blood pressure (BP) changes (delta BP < 2 
      mm Hg for both systolic and diastolic BPs, p = 0.47 and 0.33) or numbers of 
      patients reporting adverse effects (AEs) (CPZ: 16 of 35; MC: 13 of 29, p = 0.43). 
      There was no severe AE with either study drug. CONCLUSIONS: Metoclopramide and 
      chlorpromazine administered IV are both effective in the management of acute 
      migraine headache. They are associated with similar minor side-effect profiles.
FAU - Cameron, J D
AU  - Cameron JD
AD  - Department of Emergency Medicine, St. Joseph's Health Center, London, Ontario, 
      Canada.
FAU - Lane, P L
AU  - Lane PL
FAU - Speechley, M
AU  - Speechley M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic 
      Emergency Medicine
JID - 9418450
RN  - 0 (Dopamine Antagonists)
RN  - L4YEB44I46 (Metoclopramide)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chlorpromazine/administration & dosage/adverse effects/*therapeutic use
MH  - Dopamine Antagonists/administration & dosage/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Emergency Service, Hospital
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Metoclopramide/administration & dosage/adverse effects/*therapeutic use
MH  - Middle Aged
MH  - Migraine Disorders/*drug therapy
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1111/j.1553-2712.1995.tb03596.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 1995 Jul;2(7):597-602. doi: 10.1111/j.1553-2712.1995.tb03596.x.