PMID- 8521351
OWN - NLM
STAT- MEDLINE
DCOM- 19960125
LR  - 20181113
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 59
IP  - 3
DP  - 1995 Jul
TI  - Pathogenesis of in utero infection in porcine fetuses with porcine reproductive 
      and respiratory syndrome virus.
PG  - 187-92
AB  - Porcine fetuses were exposed in utero to porcine reproductive and respiratory 
      syndrome virus (PRRSV) at stages of gestation ranging from 34 to 85 days and 
      examined 17 to 31 days later to determine the effect of gestational age on fetal 
      susceptibility. For each of the 8 litters tested during the study, all of the 
      fetuses of 1 horn of the uterus were exposed to virus by intraamniotic injection; 
      those of the other horn were exposed similarly to a sham inoculum that consisted 
      of sterile cell culture medium. Viral infectivity titers associated with fetal 
      tissues collected at necropsy indicated that, regardless of gestational age, the 
      virus had replicated in fetuses exposed intraamniotically. In addition, virus had 
      also spread and replicated in sham-inoculated littermates in 3 litters. On the 
      basis of these findings it appears that there may be little or no temporal 
      difference in fetal susceptibility to infection with PRRSV. If so, the lack of 
      early fetal death as a commonly recognized feature of naturally occurring cases 
      of PRRS may be due to a greater resistance of early gestational fetuses to the 
      lethal effects of PRRSV, as suggested by this study, and/or a greater likelihood 
      of transplacental infection during late gestation.
FAU - Lager, K M
AU  - Lager KM
AD  - Virology Swine Research Unit, National Animal Disease Center, USDA, Ames, Iowa 
      50010, USA.
FAU - Mengeling, W L
AU  - Mengeling WL
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
SB  - IM
MH  - Animals
MH  - Arterivirus Infections/physiopathology/transmission/*veterinary
MH  - Female
MH  - Fetal Diseases/*veterinary/virology
MH  - Gestational Age
MH  - Infectious Disease Transmission, Vertical
MH  - Pregnancy
MH  - Swine
MH  - Swine Diseases/transmission/*virology
PMC - PMC1263764
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
PMCR- 1995/10/01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
PHST- 1995/10/01 00:00 [pmc-release]
PST - ppublish
SO  - Can J Vet Res. 1995 Jul;59(3):187-92.