PMID- 8522960
OWN - NLM
STAT- MEDLINE
DCOM- 19960124
LR  - 20221207
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 66
IP  - 1
DP  - 1996 Jan
TI  - Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: 
      implications for serotonin-dopamine interactions.
PG  - 243-9
AB  - In vivo microdialysis was used to determine whether the 
      3,4-methylenedioxymethamphetamine (MDMA)-induced release of serotonin (5-HT) in 
      vivo involves a carrier-mediated process and to investigate further the 
      state-dependent interaction between 5-HT and dopamine. MDMA produced a 
      dose-dependent increase in the extracellular concentration of 5-HT in the 
      striatum and prefrontal cortex that was attenuated by treatment with fluoxetine 
      but not by tetrodotoxin. Suppression by fluoxetine of the MDMA-induced release of 
      5-HT was accompanied by a suppression of the MDMA-induced release of dopamine. 
      Administration of MDMA to rats treated with carbidopa and L-5-hydroxytryptophan 
      resulted in a synergistic elevation of the extracellular concentration of 5-HT 
      that was much greater than that produced by either treatment alone. The 
      MDMA-induced release of dopamine by MDMA also was potentiated in 
      5-hydroxytryptophan-treated rats. These data are consistent with the view that 
      MDMA increases the extracellular concentration of 5-HT by facilitating 
      carrier-mediated 5-HT release, which can be enhanced greatly under conditions in 
      which 5-HT synthesis is stimulated. Moreover, these data are supportive of a 
      state-dependent, stimulatory role of 5-HT in the regulation of dopamine release.
FAU - Gudelsky, G A
AU  - Gudelsky GA
AD  - Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA.
FAU - Nash, J F
AU  - Nash JF
LA  - eng
GR  - DA 07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Slc6a4 protein, rat)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - MNX7R8C5VO (Carbidopa)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 5-Hydroxytryptophan/pharmacology
MH  - Animals
MH  - Carbidopa/pharmacology
MH  - Carrier Proteins/*physiology
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Dopamine/*metabolism
MH  - Drug Synergism
MH  - Fluoxetine/pharmacology
MH  - Frontal Lobe/drug effects/*metabolism
MH  - Male
MH  - Membrane Glycoproteins/*physiology
MH  - *Membrane Transport Proteins
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology/toxicity
MH  - *Nerve Tissue Proteins
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Tetrodotoxin/pharmacology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1046/j.1471-4159.1996.66010243.x [doi]
PST - ppublish
SO  - J Neurochem. 1996 Jan;66(1):243-9. doi: 10.1046/j.1471-4159.1996.66010243.x.