PMID- 8525110
OWN - NLM
STAT- MEDLINE
DCOM- 19960119
LR  - 20191023
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 59
IP  - 2
DP  - 1995 Sep
TI  - Activation of the renin-angiotensin system in dogs with asymptomatic and 
      symptomatic dilated cardiomyopathy.
PG  - 172-5
AB  - Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were 
      assessed in 23 dogs, nine of which had asymptomatic dilated cardiomyopathy (DCM) 
      (New York Heart Association [NYHA] class I), eight had symptomatic DCM (NYHA 
      class III) and six had severe congestive heart failure due to DCM (NYHA class 
      IV). None of the dogs had received any drugs before the study. PRA was increased 
      in dogs with DCM (NYHA classes III and IV) (median values 3.8 and 30.8 ng ml-1 
      hour-1) compared with normal dogs (median 0.89 ng ml-1 hour-1). However, PRA was 
      only marginally increased in dogs with DCM NYHA class I (P = 0.06). The PAC was 
      also increased in dogs with DCM (NYHA classes III and IV) (median values 123 and 
      600 pg ml-1) compared with normal dogs (median 61 pg ml-1). The PAC was not 
      significantly increased in the early stage of DCM (NYHA class I). It was 
      concluded that in dogs with DCM, the activity of the renin-angiotensin system 
      (RAS) was increased in NYHA functional classes III and IV, and that the increase 
      was correlated with the severity of the disease. The fact that the RAS tended to 
      be activated in dogs with asymptomatic DCM supports the rationale of early 
      therapeutic intervention with inhibitors of the angiotensin-converting enzyme 
      (ACE) as first line therapy in congestive heart failure.
FAU - Koch, J
AU  - Koch J
AD  - Small Animal Hospital, Department of Clinical Studies, Frederisksberg, Denmark.
FAU - Pedersen, H D
AU  - Pedersen HD
FAU - Jensen, A L
AU  - Jensen AL
FAU - Flagstad, A
AU  - Flagstad A
FAU - Poulsen, K
AU  - Poulsen K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 4964P6T9RB (Aldosterone)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Aldosterone/blood
MH  - Animals
MH  - Cardiomyopathy, Dilated/blood/physiopathology/*veterinary
MH  - *Dog Diseases
MH  - Dogs
MH  - Female
MH  - Heart Failure/etiology/physiopathology/veterinary
MH  - Male
MH  - Reference Values
MH  - Renin/blood
MH  - *Renin-Angiotensin System
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 0034-5288(95)90055-1 [pii]
AID - 10.1016/0034-5288(95)90055-1 [doi]
PST - ppublish
SO  - Res Vet Sci. 1995 Sep;59(2):172-5. doi: 10.1016/0034-5288(95)90055-1.