PMID- 8527378
OWN - NLM
STAT- MEDLINE
DCOM- 19960130
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 14
IP  - 1
DP  - 1995 Sep
TI  - Fluorescence in situ hybridization identifies new chromosomal changes involving 
      3q27 in non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement.
PG  - 1-7
AB  - Twelve B-cell non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement selected from 
      a series of 30 lymphomas with cytogenetically detectable 3qter abnormalities were 
      characterized at the histological, clinical, and cytogenetic levels, including 
      fluorescence in situ hybridization (FISH) analysis, which was performed in all 
      cases but one. A classical t(3;14) and t(3;22) were found in three patients 
      (25%). In the remaining cases, eleven different 3q27 abnormalities were 
      demonstrated and characterized with the use of chromosome painting. Seven of 
      twelve "variant" rearrangements identified in our series affecting 1p32, 1p34, 
      3p14, 6q23, 12p13, 14q11, and 16p13 have not been reported before. Moreover, 
      involvement of both homologs of chromosome 3 in distinct translocations was 
      detected as an unexpected result in two cases and was confirmed via FISH in a 
      third case. The putative bichromosomal rearrangements of the 3q27 region were 
      evidenced by Southern analysis in one of these cases. In another case, FISH with 
      a cosmid spanning the 3q27 breakpoint region demonstrated the involvement of 
      BCL6/LAZ3 only in one of two t(3q27). In our series, which was selected on 
      cytogenetic and molecular criteria, 50% (6 of 12) of cases with BCL6/LAZ3 
      rearrangement were diagnosed as diffuse, large B-cell lymphomas (DLCL). Another 
      33% (4 of 12) of cases were diagnosed as follicular center lymphomas (FL), with 
      t(14;18)/BCL2 rearrangement in all but one case. Furthermore, in three follicular 
      lymphoma cases in which multiple samples were analyzed, the disease showed no 
      evidence of histological progression during a follow-up period of 3-14 
      years.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Wlodarska, I
AU  - Wlodarska I
AD  - Center for Human Genetics, University of Leuven, Belgium.
FAU - Mecucci, C
AU  - Mecucci C
FAU - Stul, M
AU  - Stul M
FAU - Michaux, L
AU  - Michaux L
FAU - Pittaluga, S
AU  - Pittaluga S
FAU - Hernandez, J M
AU  - Hernandez JM
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
FAU - Van den Berghe, H
AU  - Van den Berghe H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (BCL6 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cells, Cultured
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Retrospective Studies
MH  - Transcription Factors/*genetics
MH  - Zinc Fingers/*genetics
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1002/gcc.2870140102 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Sep;14(1):1-7. doi: 10.1002/gcc.2870140102.