PMID- 8527397
OWN - NLM
STAT- MEDLINE
DCOM- 19960126
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 14
IP  - 2
DP  - 1995 Oct
TI  - Chromosomes in gliomatosis cerebri.
PG  - 149-53
AB  - Gliomatosis cerebri is a rare brain tumor which histologically resembles a 
      diffuse cerebral astrocytoma. It can simultaneously infiltrate multiple sites in 
      the cerebrum, cerebellum, brainstem, and spinal cord. This remarkable diffuseness 
      has led to the idea that gliomatosis cerebri does not derive from a solitary 
      focus but must arise from a broad field of glial cells. We studied the 
      chromosomes from gliomatosis cerebri in a 12-year-old boy by conventional 
      cytogenetics and fluorescence in situ hybridization (FISH). Aside from normal 
      cells, we found a majority of cells with the karyotype 
      44,XY,del(6)(q25),del(14)(q21), 
      der(15;21)(q10;q10),add(18)(q22),del(19)(p12),add(20)(p13),-21. A smaller 
      proportion of cells had 88 chromosomes with a doubling of this abnormal 
      karyotype. These findings are consistent with a clonal neoplasm stemming from a 
      single cell. The chromosome changes we observed, with the possible exception of 
      the chromosome 6 deletion, did not resemble those frequently found in 
      astrocytomas. Gliomatosis cerebri may therefore belong to a separate category of 
      brain tumors.
FAU - Hecht, B K
AU  - Hecht BK
AD  - Laboratory of Molecular Genetics of Human Cancers, URA CNRS 1462, Nice, France.
FAU - Turc-Carel, C
AU  - Turc-Carel C
FAU - Chatel, M
AU  - Chatel M
FAU - Lonjon, M
AU  - Lonjon M
FAU - Roche, J L
AU  - Roche JL
FAU - Gioanni, J
AU  - Gioanni J
FAU - Hecht, F
AU  - Hecht F
FAU - Gaudray, P
AU  - Gaudray P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Brain Neoplasms/classification/*genetics/pathology
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - *Chromosome Disorders
MH  - Chromosome Mapping
MH  - Glioma/classification/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Magnetic Resonance Imaging
MH  - Male
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1002/gcc.2870140210 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Oct;14(2):149-53. doi: 10.1002/gcc.2870140210.