PMID- 8527903
OWN - NLM
STAT- MEDLINE
DCOM- 19960126
LR  - 20211203
IS  - 1023-294X (Print)
IS  - 1023-294X (Linking)
VI  - 74
DP  - 1995
TI  - The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis.
PG  - 89-121
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) can elicit a wide variety of 
      effects upon cells expressing its receptor, the tyrosine kinase proto-oncogene 
      product Met, including mitogenicity, motility, and morphogenesis. Normally, met 
      expression is restricted to epithelial cells and is activated in a paracrine 
      fashion by HGF/SF secreted from cells of mesenchymal origin. In this chapter, we 
      review data showing that: (i) met over-expression in HGF/SF-expressing NIH/3T3 
      fibroblasts leads to sarcomagenesis and metastasis via an autocrine mechanism; 
      (ii) Met-HGF/SF autocrine signalling occurs to a low level in normal fibroblasts 
      and to a much greater extent in human sarcomas and sarcoma cell lines; (iii) met 
      expression is enhanced as p53-deficient fibroblasts are passaged in vitro and 
      (iv) met and HGF/SF over-expression are selected for during tumorigenesis of 
      p53-deficient late-passage fibroblasts. Thus, loss of p53 predisposes a 
      mesenchymal cell to over-express met and high level Met-HGF/SF autocrine 
      signaling in mesenchymal cells promotes both sarcomagenesis and metastasis 
      through inappropriate induction of the pleiotropic responses to Met-HGF/SF 
      stimulation.
FAU - Cortner, J
AU  - Cortner J
AD  - ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, 
      MD 21702, USA.
FAU - Vande Woude, G F
AU  - Vande Woude GF
FAU - Rong, S
AU  - Rong S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - EXS
JT  - EXS
JID - 9204529
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - *Gene Expression
MH  - Hepatocyte Growth Factor/biosynthesis/*physiology
MH  - Humans
MH  - Mice
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-met
MH  - Proto-Oncogenes
MH  - Receptor Protein-Tyrosine Kinases/biosynthesis/metabolism/physiology
MH  - Sarcoma/*pathology/*physiopathology
MH  - Sarcoma, Experimental/pathology/physiopathology
MH  - *Signal Transduction
MH  - Tumor Cells, Cultured
RF  - 101
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/978-3-0348-9070-0_6 [doi]
PST - ppublish
SO  - EXS. 1995;74:89-121. doi: 10.1007/978-3-0348-9070-0_6.