PMID- 8528579
OWN - NLM
STAT- MEDLINE
DCOM- 19960201
LR  - 20190512
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 116
IP  - 2
DP  - 1995 Sep
TI  - Restoration of blood pressure by choline treatment in rats made hypotensive by 
      haemorrhage.
PG  - 1911-7
AB  - 1. Intracerebroventricular (i.c.v.) injection of choline (25-150 micrograms) 
      increased blood pressure in rats made acutely hypotensive by haemorrhage. 
      Intraperitoneal administration of choline (60 mg kg-1) also increased blood 
      pressure, but to a lesser extent. Following i.c.v. injection of 25 micrograms or 
      50 micrograms of choline, heart rate did not change, while 100 micrograms or 150 
      micrograms i.c.v. choline produced a slight and short lasting bradycardia. 
      Choline (150 micrograms) failed to alter the circulating residual volume of blood 
      in haemorrhaged rats. 2. The pressor response to i.c.v. choline (50 micrograms) 
      in haemorrhaged rats was abolished by pretreatment with mecamylamine (50 
      micrograms, i.c.v.) but not atropine (10 micrograms, i.c.v.). The pressor 
      response to choline was blocked by pretreatment with hemicholinium-3 (20 
      micrograms, i.c.v.). 3. The pressor response to i.c.v. choline (150 micrograms) 
      was associated with a several fold increase in plasma levels of vasopressin and 
      adrenaline but not of noradrenaline and plasma renin. 4. The pressor response to 
      i.c.v. choline (150 micrograms) was not altered by bilateral adrenalectomy, but 
      was attenuated by systemic administration of either phentolamine (10 mg kg-1) or 
      the vasopressin antagonist 
      [beta-mercapto-beta,beta-cyclopenta-methylenepropionyl1, 
      O-Me-Tyr2,Arg8]-vasopressin (10 micrograms kg-1). 5. It is concluded that the 
      precursor of acetylcholine, choline, can increase and restore blood pressure in 
      acutely haemorrhaged rats by increasing central cholinergic neurotransmission. 
      Nicotinic receptor activation and an increase in plasma vasopressin and 
      adrenaline level appear to be involved in this effect of choline.
FAU - Ulus, I H
AU  - Ulus IH
AD  - Uludag University Medical Faculty, Department of Pharmacology, Bursa, Turkey.
FAU - Arslan, B Y
AU  - Arslan BY
FAU - Savci, V
AU  - Savci V
FAU - Kiran, B K
AU  - Kiran BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 7C0697DR9I (Atropine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Choline/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hemorrhage
MH  - Hypotension
MH  - Injections, Spinal
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
PMC - PMC1909109
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
PMCR- 1996/09/01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PHST- 1996/09/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1995.tb16682.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1995 Sep;116(2):1911-7. doi: 10.1111/j.1476-5381.1995.tb16682.x.