PMID- 8529314
OWN - NLM
STAT- MEDLINE
DCOM- 19960130
LR  - 20131121
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 44
IP  - 2
DP  - 1995 Aug
TI  - Serum immunoglobulin E in primary IgA nephropathy.
PG  - 86-90
AB  - The biosynthesis of human immunoglobulin E (IgE) is regulated by a complex 
      network involving T and B lymphocytes. Diseases associated with high serum IgE 
      (sIgE) levels are usually characterized by T cell disorders. Total sIgE level has 
      been found to be of clinical relevance in minimal change nephrotic syndrome. 
      However, the clinical significance has rarely been studied in primary IgA 
      nephropathy (IgA N). We retrospectively studied 99 cases of primary IgA N. There 
      were 59 males and 40 females with a mean age of 30.0 +/- 12.1 years. The mean 
      follow-up duration was 45.9 +/- 31.1 months. Pathological grading was done 
      according to the criteria of Meadow et al. Median sIgE for the entire group was 
      122.0 IU/ml (range: 2.8-5805 IU/ml) which was significantly higher than the 
      healthy control group (median: 43,7 IU/ml, range: 5.0-1003 IU/ml, p < 0.001). 
      However, when the IgA N cases were stratified into grades, only grade I (median: 
      514 IU/ml, range: 72.1-5805.0 IU/ml) and grade II (median: 229 IU/ml, range: 
      5.0-5464 IU/ml) patients had significantly higher sIgE than the control group (p 
      < 0.0005 and p < 0.001 respectively). Patients with nephrotic ranged proteinuria 
      (32 cases) were further classified into "stable" and "progressive" groups. The 
      "stable" group had a significantly higher sIgE level (median: 922.0 IU/ml, range: 
      2.8-5805 IU/ml), compared to that of the "progressive" group (median: 55.3 IU/ml, 
      range: 5.0-1600 IU/ml, p < 0.02). The effect of aggressive treatment (including 
      corticosteroid and/or cyclophosphamide, cyclosporine) was also assessed.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Shu, K H
AU  - Shu KH
AD  - Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, 
      Republic of China.
FAU - Lu, Y S
AU  - Lu YS
FAU - Chen, C H
AU  - Chen CH
FAU - Sheu, S S
AU  - Sheu SS
FAU - Chan, L P
AU  - Chan LP
FAU - Lian, J D
AU  - Lian JD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 37341-29-0 (Immunoglobulin E)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Creatinine/blood
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerulonephritis, IGA/complications/*metabolism/pathology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Proteinuria/etiology/metabolism
MH  - Regression Analysis
MH  - Retrospective Studies
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1995 Aug;44(2):86-90.