PMID- 8530258
OWN - NLM
STAT- MEDLINE
DCOM- 19960131
LR  - 20190920
IS  - 0162-3109 (Print)
IS  - 0162-3109 (Linking)
VI  - 30
IP  - 2
DP  - 1995 Aug
TI  - Suppression of human immunoglobulin E antibody production by a new naphthalene 
      derivative.
PG  - 167-76
AB  - A new naphthalene derivative, (E)-2-(7-(2-naphthyl)-6-heptenamide)benzoic acid 
      (TEI-8364) was assessed for its effect on interleukin (IL)-4- and anti-CD40 
      monoclonal antibody-induced immunoglobulin E (IgE) production by cultured human 
      lymphocytes. TEI-8364 preferentially suppressed the production of IgE by 
      peripheral blood mononuclear cells (PBMC) in a dose-dependent manner, without 
      inhibiting PBMC proliferation. In addition, TEI-8364, at a concentration of 10 
      microM, completely inhibited IL-4- and anti-CD40-induced IgE production by 
      purified tonsillar B lymphocytes, suggesting that TEI-8364 affects B cells by 
      interfering with signals provided by IL-4 or through CD40 and IL-4. TEI-8364 also 
      had a profound inhibiting effect on the in vitro production of specific antibody 
      to a T cell-dependent antigen by PBMC from an immunized volunteer, cultured in 
      the presence of antigen. Furthermore, TEI-8364 at a dose of 1 mg/mouse/day 
      selectively inhibited IgE production by severe combined immunodeficiency mice 
      engrafted with human PBMC, if the drug was administered subcutaneously for five 
      consecutive days. These findings suggest that TEI-8364 is a potent therapeutic 
      agent that may be useful in the treatment of IgE-mediated allergic disorders.
FAU - Uejima, Y
AU  - Uejima Y
AD  - Pharmaceutical Discovery Research Laboratory, Teijin Institute for Biomedical 
      Research, Tokyo, Japan.
FAU - Takahashi, K
AU  - Takahashi K
FAU - Komoriya, K
AU  - Komoriya K
FAU - Kurozumi, S
AU  - Kurozumi S
FAU - Ochs, H D
AU  - Ochs HD
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Immunopharmacology
JT  - Immunopharmacology
JID - 7902474
RN  - 0 (Amides)
RN  - 0 (Benzoates)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (TEI 8364)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Amides/*pharmacology
MH  - Animals
MH  - B-Lymphocytes/drug effects/immunology/transplantation
MH  - *Benzoates/*pharmacology
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunosuppressive Agents/*pharmacology
MH  - In Vitro Techniques
MH  - Lymphocyte Activation/drug effects
MH  - Male
MH  - Mice
MH  - Mice, SCID
MH  - Transplantation, Heterologous
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 016231099500021K [pii]
AID - 10.1016/0162-3109(95)00021-k [doi]
PST - ppublish
SO  - Immunopharmacology. 1995 Aug;30(2):167-76. doi: 10.1016/0162-3109(95)00021-k.