PMID- 8531856
OWN - NLM
STAT- MEDLINE
DCOM- 19960130
LR  - 20071114
IS  - 0098-1532 (Print)
IS  - 0098-1532 (Linking)
VI  - 26
IP  - 2
DP  - 1996 Feb
TI  - Renal failure in Wilms' tumor patients: a report from the National Wilms' Tumor 
      Study Group.
PG  - 75-80
AB  - This report defines the incidence and determines the etiology of renal failure 
      (RF) in patients undergoing treatment for Wilms' tumor (WT). The database of the 
      National Wilms' Tumor Study (NWTS) was searched to identify all children reported 
      to have developed chronic renal failure. There were 55 patients found to have RF. 
      Of these, 39 patients had bilateral tumors, 15 with unilateral disease and one 
      with a WT in a solitary kidney. The median interval from diagnosis to the onset 
      of renal failure was 21 months. The incidence of RF in bilateral WT was 16.4% for 
      NWTS-1 & -2, 9.9% for NWTS-3, and 3.8% for NWTS-4. The incidence of RF in 
      unilateral WT remained stable. The most common etiologies of RF were: bilateral 
      nephrectomy for persistent or recurrent tumor (24 pts), Drash syndrome (12 pts), 
      progressive tumor in the remaining kidney (5 pts), radiation nephritis (6 pts), 
      and other causes (5 pts). The etiology of renal failure was not reported in three 
      children. Children with unilateral WT and a normal contralateral kidney have a 
      very low incidence of RF, and this review does not support a recommendation for 
      parenchymal sparing procedures in these patients. Children with bilateral WT are 
      at risk for the development of RF, and parenchymal sparing procedures are 
      warranted.
FAU - Ritchey, M L
AU  - Ritchey ML
AD  - Department of Surgery, University of Texas-Houston Medical School, USA.
FAU - Green, D M
AU  - Green DM
FAU - Thomas, P R
AU  - Thomas PR
FAU - Smith, G R
AU  - Smith GR
FAU - Haase, G
AU  - Haase G
FAU - Shochat, S
AU  - Shochat S
FAU - Moksness, J
AU  - Moksness J
FAU - Breslow, N E
AU  - Breslow NE
LA  - eng
GR  - CA-42326/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Pediatr Oncol
JT  - Medical and pediatric oncology
JID - 7506654
SB  - IM
CIN - Med Pediatr Oncol. 1997 Mar;28(3):239-40. PMID: 9024526
MH  - Child
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Failure, Chronic/*etiology
MH  - Kidney Neoplasms/*complications/therapy
MH  - Wilms Tumor/*complications/therapy
EDAT- 1996/02/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-911X(199602)26:2<75::AID-MPO1>3.0.CO;2-R [pii]
AID - 10.1002/(SICI)1096-911X(199602)26:2<75::AID-MPO1>3.0.CO;2-R [doi]
PST - ppublish
SO  - Med Pediatr Oncol. 1996 Feb;26(2):75-80. doi: 
      10.1002/(SICI)1096-911X(199602)26:2<75::AID-MPO1>3.0.CO;2-R.