PMID- 8533166
OWN - NLM
STAT- MEDLINE
DCOM- 19960201
LR  - 20220316
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Linking)
VI  - 11
IP  - 12
DP  - 1995 Dec
TI  - The HLA system and the analysis of multifactorial genetic disease.
PG  - 493-8
AB  - The human leukocyte antigen (HLA) system comprises closely linked genes 
      controlling highly polymorphic proteins involved in the presentation of peptides 
      to the T-cell receptor. Specific alleles at HLA loci are associated with 
      diseases, often those suspected to be of autoimmune aetiology. Many of these 
      associations result from linkage disequilibrium between the HLA gene studied and 
      other HLA genes or non-HLA genes close by. Owing to its high level of 
      polymorphism and its candidate role in many diseases, HLA was the first system 
      used in many techniques of genetic mapping, such as affected-sib-pair analysis 
      and association (linkage disequilibrium) studies. Much remains unknown about the 
      reasons why diseases are associated with HLA. Experience gained from HLA has, 
      however, shown how other loci involved in complex traits can be identified by 
      studying families with multiple affected cases or sib pairs, followed by 
      linkage-disequilibrium mapping and then analysis of candidate genes.
FAU - Tomlinson, I P
AU  - Tomlinson IP
AD  - Cancer Genetics Laboratory, Imperial Cancer Research Fund, London, UK.
FAU - Bodmer, W F
AU  - Bodmer WF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoimmune Diseases/genetics/immunology
MH  - Chromosome Mapping
MH  - Diabetes Mellitus, Type 1/genetics/immunology
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - Genetic Diseases, Inborn/*genetics/immunology
MH  - Genetic Markers
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - *Major Histocompatibility Complex
MH  - Pseudogenes
RF  - 49
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - S0168-9525(00)89159-3 [pii]
AID - 10.1016/s0168-9525(00)89159-3 [doi]
PST - ppublish
SO  - Trends Genet. 1995 Dec;11(12):493-8. doi: 10.1016/s0168-9525(00)89159-3.