PMID- 8537912
OWN - NLM
STAT- MEDLINE
DCOM- 19960208
LR  - 20190914
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 24
IP  - 9
DP  - 1995 Oct
TI  - A fluorescence in situ hybridization (FISH) analysis with centromere-specific DNA 
      probes of chromosomes 3 and 17 in pleomorphic adenomas and adenoid cystic 
      carcinomas.
PG  - 398-401
AB  - Aberrations of chromosomes 3 and 17 were studied by FISH using 
      centromere-specific DNA probes in 11 salivary adenoid cystic carcinomas (ACC) and 
      8 salivary pleomorphic adenomas (PA), with 3 lymph nodes as controls. Two 
      hybridized signals were detected in 92.8 +/- 2.7% of controls, 73.2 +/- 7.0% of 
      PA and 66.8 +/- 7.9% of ACC cells for chromosome 3, and in 90.4 +/- 2.3% of 
      controls, 59.5 +/- 25.0% of PA and 44.8 +/- 20.2% of ACC for chromosome 17. More 
      than 3 hybridized signals, which indicate polysomy, were observed in 3.1% of 
      controls, 15.5% of PA and 22.9% of ACC cells for chromosome 3, and in 1.2% of 
      controls, 10.3% of PA and 23.1% of ACC cells for chromosome 17. A single 
      hybridized signal was much more frequent for chromosome 17 than for chromosome 3. 
      These findings suggest that polysomy of both chromosomes occurs during the 
      development of salivary gland tumors, and its frequency is increased in adenoid 
      cystic carcinoma as compared to pleomorphic adenoma. In addition, monosomy of 
      chromosome 17 could possibly be significant in salivary gland tumors.
FAU - Li, X
AU  - Li X
AD  - Department of Oral and Maxillofacial Surgery, Yamaguchi University School of 
      Medicine, Ube, Japan.
FAU - Tsuji, T
AU  - Tsuji T
FAU - Wen, S
AU  - Wen S
FAU - Mimura, Y
AU  - Mimura Y
FAU - Wang, Z
AU  - Wang Z
FAU - Sasaki, K
AU  - Sasaki K
FAU - Shinozaki, F
AU  - Shinozaki F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adenoma, Pleomorphic/*genetics/ultrastructure
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - Carcinoma, Adenoid Cystic/*genetics/ultrastructure
MH  - Centromere/*genetics/ultrastructure
MH  - Chromosome Aberrations/genetics
MH  - Chromosomes, Human, Pair 17/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 3/*genetics/ultrastructure
MH  - *DNA Probes
MH  - DNA, Neoplasm/*analysis
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/metabolism/ultrastructure
MH  - Middle Aged
MH  - Salivary Gland Neoplasms/*genetics
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1111/j.1600-0714.1995.tb01208.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 1995 Oct;24(9):398-401. doi: 
      10.1111/j.1600-0714.1995.tb01208.x.