PMID- 8538028
OWN - NLM
STAT- MEDLINE
DCOM- 19960206
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 53
IP  - 11
DP  - 1995 Nov
TI  - [Familial pituitary tumors].
PG  - 2691-6
AB  - Familial pituitary tumors are relatively rare. Most commonly, they occur as a 
      part of multiple endocrine neoplasia type 1 (MEN 1). However, familial pituitary 
      adenomas unrelated MEN 1 (familial pituitary adenomas) are extremely rare. In 
      review of MEN 1 in Japan, 60% of the patients with MEN 1 had pituitary tumors. 
      Only 45 cases of familial pituitary adenomas have been reported from 20 families. 
      In our review of familial pituitary adenomas, 30 (67%) of 45 reported cases are 
      acromegaly or gigantism. This incidence is much higher than 28% in MEN 1 patients 
      with pituitary tumors. Allelic deletions at 11q13 were identified in MEN 1 
      associated pituitary adenomas and familial pituitary adenomas in two gigantism 
      brothers.
FAU - Yoshimoto, K
AU  - Yoshimoto K
AD  - Otsuka Department of Clinical and Molecular Nutrition, University of Tokushima.
FAU - Saito, S
AU  - Saito S
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Acromegaly
MH  - Adenoma/*genetics
MH  - Adult
MH  - Alleles
MH  - Chromosomes, Human, Pair 11
MH  - Family Health
MH  - Female
MH  - Gene Deletion
MH  - Gigantism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Pituitary Neoplasms/*genetics
RF  - 21
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1995 Nov;53(11):2691-6.