PMID- 8538030
OWN - NLM
STAT- MEDLINE
DCOM- 19960206
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 53
IP  - 11
DP  - 1995 Nov
TI  - [Multiple endocrine neoplasia type I].
PG  - 2702-7
AB  - Multiple endocrine neoplasia type 1 (MEN1) is characterized by the combined 
      occurrence of primary hyperparathyroidism, pancreatic endocrine tumors, and 
      neoplasms of the anterior pituitary gland. The disease is inherited as an 
      autosomal dominant disorder with a high penetrance. Although many investigators 
      have localized the causative genes to chromosome 11q3 by linkage analysis, the 
      MEN1 gene remains unidentified. The use of molecular genetic markers in family 
      linkage studies, however, have made it possible to identify gene carriers. 
      Repetitive screening combined with the assignment of gene-carrier status will 
      provide possibilities for therapeutic or prophylactic intervention earlier in the 
      development of each of the manifestations of this syndrome, such as 
      gastrointestinal bleeding secondary to ulcers or malignant transformation.
FAU - Kawa, S
AU  - Kawa S
AD  - Second Department of Internal Medicine, Shinshu University School of Medicine.
FAU - Karasawa, Y
AU  - Karasawa Y
FAU - Oguchi, H
AU  - Oguchi H
FAU - Furuta, S
AU  - Furuta S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 9007-49-2 (DNA)
RN  - EC 2.4.1.- (Phosphorylases)
SB  - IM
MH  - DNA
MH  - Genes, Tumor Suppressor
MH  - Genetic Linkage
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Muscle, Skeletal/enzymology
MH  - Phosphorylases/genetics
RF  - 17
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1995 Nov;53(11):2702-7.