PMID- 8541486 OWN - NLM STAT- MEDLINE DCOM- 19960213 LR - 20220311 IS - 0959-4965 (Print) IS - 0959-4965 (Linking) VI - 6 IP - 13 DP - 1995 Sep 11 TI - Age-related functional differences between auditory cortices: a whole-head MEG study. PG - 1803-6 AB - Auditory evoked magnetic fields (AEFs) were recorded from 10 healthy younger and 10 older subjects using a whole-head magnetometer. Two blocks of tone pips were presented to the left ear with constant inter-stimulus intervals (ISIs) of 0.5 and 2.5 s. The amplitude of P50m, unlike that of N100m, was larger in the older subjects. In both groups, the peak latencies of P50m and N100m responses were significantly shorter over the contralateral than ipsilateral cortex. The interhemispheric latency difference of N100m was significantly increased with age. These findings suggest that ageing delays signal processing in the ipsilateral auditory cortex and that ageing affects consecutive AEFs in a different manner. FAU - Pekkonen, E AU - Pekkonen E AD - Department of Psychology, University of Helsinki, Finland. FAU - Huotilainen, M AU - Huotilainen M FAU - Virtanen, J AU - Virtanen J FAU - Sinkkonen, J AU - Sinkkonen J FAU - Rinne, T AU - Rinne T FAU - Ilmoniemi, R J AU - Ilmoniemi RJ FAU - Naatanen, R AU - Naatanen R LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 SB - IM MH - Acoustic Stimulation MH - Adult MH - Aged MH - Aged, 80 and over MH - Aging/*physiology MH - Analysis of Variance MH - Auditory Cortex/*physiology MH - Evoked Potentials, Auditory/*physiology MH - Female MH - Functional Laterality/physiology MH - Humans MH - Magnetics MH - Male MH - Middle Aged MH - Reaction Time/physiology EDAT- 1995/09/11 00:00 MHDA- 1995/09/11 00:01 CRDT- 1995/09/11 00:00 PHST- 1995/09/11 00:00 [pubmed] PHST- 1995/09/11 00:01 [medline] PHST- 1995/09/11 00:00 [entrez] AID - 10.1097/00001756-199509000-00023 [doi] PST - ppublish SO - Neuroreport. 1995 Sep 11;6(13):1803-6. doi: 10.1097/00001756-199509000-00023.