PMID- 8543697
OWN - NLM
STAT- MEDLINE
DCOM- 19960209
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 34
IP  - 1
DP  - 1996 Jan
TI  - Clinical and histologic spectrum of human T-cell lymphotropic virus type 
      I-associated lymphoma involving the skin.
PG  - 69-76
AB  - BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is associated with infection 
      with human T-cell lymphotropic virus type I (HTLV-I). OBJECTIVE: The objective 
      was to describe the clinical, histopathologic, and immunologic features in three 
      patients with ATL involving the skin. METHODS: Clinical histories and skin biopsy 
      specimens were reviewed. Immunophenotypic studies were performed on peripheral 
      blood lymphocytes (three patients) and on skin biopsy specimens (one patient). 
      RESULTS: Serologic testing in each patient was positive for HTLV-I. Specific 
      cutaneous lesions of ATL were diverse. Histologic features included markedly 
      epidermotropic lymphoid infiltrates and dermal aggregates of lymphocytes and 
      macrophages resembling granulomas. One patient died 3 months after diagnosis; the 
      other two are alive with residual lymphoma. CONCLUSION: A spectrum of clinical, 
      histologic, and immunophenotypic features are seen in ATL involving skin. Those 
      cases with a chronic course may resemble mycosis fungoides clinically and 
      histologically. Serologic testing for HTLV-I is recommended in all patients with 
      cutaneous lymphoma from endemic areas and in those with other risk factors for 
      HTLV-I infection.
FAU - DiCaudo, D J
AU  - DiCaudo DJ
AD  - Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Perniciaro, C
AU  - Perniciaro C
FAU - Worrell, J T
AU  - Worrell JT
FAU - White, J W Jr
AU  - White JW Jr
FAU - Cockerell, C J
AU  - Cockerell CJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (HTLV-I Antibodies)
SB  - IM
CIN - J Am Acad Dermatol. 1997 Jan;36(1):133-4. PMID: 8996285
CIN - J Am Acad Dermatol. 1997 Jan;36(1):134-5. PMID: 8996286
MH  - Adult
MH  - Female
MH  - HTLV-I Antibodies/analysis
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/immunology/*pathology
MH  - Middle Aged
MH  - Skin Neoplasms/immunology/*pathology
EDAT- 1996/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - S0190-9622(96)90836-1 [pii]
AID - 10.1016/s0190-9622(96)90836-1 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1996 Jan;34(1):69-76. doi: 10.1016/s0190-9622(96)90836-1.