PMID- 8544777
OWN - NLM
STAT- MEDLINE
DCOM- 19960212
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 45
IP  - 1
DP  - 1996 Jan
TI  - Antioxidant defense system in lung of male and female rats: interactions with 
      alcohol, copper, and type of dietary carbohydrate.
PG  - 49-56
AB  - Male and female rats were used to investigate the effects of type of dietary 
      carbohydrate (CHO), copper, and ethanol consumption on lung antioxidant enzyme 
      activities and levels of phosphorylated compounds in whole blood. 
      Copper-deficient female rats exhibited a greater degree of copper deficiency than 
      males, as assessed by hepatic copper concentration and hepatic copper superoxide 
      dismutase (CuSOD) activity. However, copper-deficient male rats fed 
      fructose-containing diets exhibited greater growth retardation, anemia, and heart 
      hypertrophy than females consuming the same diets and males fed starch. In 
      addition, one of 10 copper-deficient male rats that ate a fructose-based diet and 
      drank water and one of 10 copper-deficient male rats that ate a starch-based diet 
      and drank ethanol died. Copper-deficient, starch-fed males exhibited the highest 
      activities of glutathione peroxidase (GSH-Px) and catalase as compared with 
      fructose-fed rats. Ethanol consumption elevated the activities of GSH-Px and 
      catalase. Copper-deficient female rats exhibited higher catalase but lower GSH-Px 
      activities than males. It is suggested that in copper deficiency, the ability to 
      increase antioxidant enzyme activities in rats consuming starch is greater than 
      in rats consuming fructose. Rats fed starch are provided with a greater degree of 
      protection against oxidative damage than rats fed fructose. In addition, 
      polyphosphorylated compounds in blood were reduced in copper-deficient male rats 
      that consumed fructose-based diets. This may impair supply of oxygen to tissues.
FAU - Fields, M
AU  - Fields M
AD  - Beltsville Human Nutrition Research Center, US Department of Agriculture, 
      Agricultural Research Service, MD 20705, USA.
FAU - Lewis, C G
AU  - Lewis CG
FAU - Lure, M D
AU  - Lure MD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Antioxidants)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Phosphates)
RN  - 30237-26-4 (Fructose)
RN  - 3K9958V90M (Ethanol)
RN  - 789U1901C5 (Copper)
RN  - 9005-25-8 (Starch)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Alcohol Drinking/metabolism
MH  - Anemia/epidemiology/etiology
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Cardiomegaly/epidemiology/etiology
MH  - Catalase/analysis
MH  - Copper/analysis/deficiency/*metabolism
MH  - Dietary Carbohydrates/*metabolism
MH  - Ethanol/*metabolism
MH  - Female
MH  - Fructose/metabolism/pharmacology
MH  - Glutathione Peroxidase/analysis
MH  - Growth Disorders/epidemiology/etiology
MH  - Hematocrit
MH  - Incidence
MH  - Liver/chemistry/enzymology
MH  - Lung/*metabolism
MH  - Male
MH  - Phosphates/blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
MH  - Starch/metabolism/pharmacology
MH  - Superoxide Dismutase/analysis
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - S0026-0495(96)90199-7 [pii]
AID - 10.1016/s0026-0495(96)90199-7 [doi]
PST - ppublish
SO  - Metabolism. 1996 Jan;45(1):49-56. doi: 10.1016/s0026-0495(96)90199-7.