PMID- 8545283
OWN - NLM
STAT- MEDLINE
DCOM- 19960212
LR  - 20180823
IS  - 0270-4137 (Print)
IS  - 0270-4137 (Linking)
VI  - 28
IP  - 1
DP  - 1996 Jan
TI  - Presentation of prostate tumor antigens by dendritic cells stimulates T-cell 
      proliferation and cytotoxicity.
PG  - 65-9
AB  - Dendritic cells (DCs) are "professional" antigen-presenting cells capable of 
      stimulating T-cell proliferation and cytotoxicity when loaded with and presenting 
      specific antigens, including tumor antigens. We demonstrated the stimulation of 
      an autologous cytotoxic T-cell response elicited by DC loaded with autologous 
      tumor cell lysate derived from primary prostate tumor. A candidate tumor antigen 
      is prostate-specific membrane antigen (PSMA), which is overexpressed in prostate 
      cancer patients. We identified a HLA-A2 motif in PSMA, isolated patient DC, 
      loaded peptide into DC, and stimulated autologous T cells to proliferate. The 
      ability to use DC for presentation of either tumor or peptide antigen in an 
      HLA-restricted fashion in order to stimulate T-cell proliferation and 
      cytotoxicity demonstrates the potential of this technology for development of a 
      prostate cancer vaccine.
FAU - Tjoa, B
AU  - Tjoa B
AD  - Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, Washington 
      98125, USA.
FAU - Boynton, A
AU  - Boynton A
FAU - Kenny, G
AU  - Kenny G
FAU - Ragde, H
AU  - Ragde H
FAU - Misrock, S L
AU  - Misrock SL
FAU - Murphy, G
AU  - Murphy G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - 0 (HLA-A Antigens)
RN  - EC 3.4.17.21 (FOLH1 protein, human)
RN  - EC 3.4.17.21 (Glutamate Carboxypeptidase II)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, Neoplasm/analysis/*pharmacology
MH  - Antigens, Surface/analysis/*pharmacology
MH  - Cell Division/drug effects
MH  - Cytotoxicity, Immunologic/*drug effects
MH  - Dendritic Cells/*immunology/physiology
MH  - Glutamate Carboxypeptidase II
MH  - HLA-A Antigens
MH  - Humans
MH  - Immunotherapy, Active
MH  - Male
MH  - Molecular Sequence Data
MH  - Prostatic Neoplasms/*immunology/pathology/therapy
MH  - T-Lymphocytes/*drug effects
MH  - Tumor Cells, Cultured
EDAT- 1996/01/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1002/(SICI)1097-0045(199601)28:1<65::AID-PROS9>3.0.CO;2-N [pii]
AID - 10.1002/(SICI)1097-0045(199601)28:1<65::AID-PROS9>3.0.CO;2-N [doi]
PST - ppublish
SO  - Prostate. 1996 Jan;28(1):65-9. doi: 
      10.1002/(SICI)1097-0045(199601)28:1<65::AID-PROS9>3.0.CO;2-N.