PMID- 8547448
OWN - NLM
STAT- MEDLINE
DCOM- 19960220
LR  - 20131121
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 38
IP  - 4
DP  - 1995 Aug 15
TI  - Prefrontal cortical and hippocampal modulation of haloperidol-induced catalepsy 
      and apomorphine-induced stereotypic behaviors in the rat.
PG  - 255-62
AB  - Effects of prefrontal cortical or hippocampal excitotoxic lesions on behavioral 
      parameters related to dopaminergic transmission in the basal ganglia were 
      investigated in the rat. We examined haloperidol-induced catalepsy and 
      apomorphine-induced stereotypic behaviors after ibotenic acid lesions of the 
      medial prefrontal cortex (MPFC), dorsal (DH), or ventral hippocampus (VH) in 
      adult rats. Haloperidol-induced (1 mg/kg) catalepsy was decreased in rats with 
      either MPFC or VH but not DH lesions. While both DH and VH lesioned animals 
      demonstrated a reduction in apomorphine-induced (0.75 mg/kg) stereotypic 
      behaviors, the VH lesioned animals also showed an enhancement of locomotor 
      activity. MPFC lesioned rats tended towards potentiation of stereotypic behaviors 
      and reduced locomotion after apomorphine administration. These data indicate that 
      loss of prefrontal cortical or hippocampal modulation leads to an enhancement of 
      DA transmission within the basal ganglia, though the pattern of augmentation 
      depends on the area lesioned.
FAU - Lipska, B K
AU  - Lipska BK
AD  - National Institute of Mental Health, Clinical Brain Disorders Branch, Washington, 
      DC, USA.
FAU - Jaskiw, G E
AU  - Jaskiw GE
FAU - Braun, A R
AU  - Braun AR
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Antipsychotic Agents)
RN  - J6292F8L3D (Haloperidol)
RN  - N21FAR7B4S (Apomorphine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antiparkinson Agents/*adverse effects/*pharmacology
MH  - Antipsychotic Agents/*adverse effects/*pharmacology
MH  - Apomorphine/*adverse effects/*pharmacology
MH  - Basal Ganglia/drug effects
MH  - Catalepsy/*chemically induced
MH  - Dopamine/metabolism
MH  - Haloperidol/*adverse effects/*pharmacology
MH  - Hippocampus/*drug effects/physiopathology
MH  - Locomotion/drug effects
MH  - Male
MH  - Prefrontal Cortex/*drug effects/physiopathology
MH  - Rats
MH  - *Rats, Sprague-Dawley
MH  - Stereotyped Behavior/*drug effects
EDAT- 1995/08/15 00:00
MHDA- 1995/08/15 00:01
CRDT- 1995/08/15 00:00
PHST- 1995/08/15 00:00 [pubmed]
PHST- 1995/08/15 00:01 [medline]
PHST- 1995/08/15 00:00 [entrez]
AID - 0006-3223(94)00261-Z [pii]
AID - 10.1016/0006-3223(94)00261-Z [doi]
PST - ppublish
SO  - Biol Psychiatry. 1995 Aug 15;38(4):255-62. doi: 10.1016/0006-3223(94)00261-Z.