PMID- 8547602 OWN - NLM STAT- MEDLINE DCOM- 19960222 LR - 20190718 IS - 0959-4965 (Print) IS - 0959-4965 (Linking) VI - 6 IP - 14 DP - 1995 Oct 2 TI - Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. PG - 1937-41 AB - Recent data have suggested the involvement of neurotrophins in the cascade of events occurring during seizure development. In particular, expression of both brain-derived neurotrophic factor (BDNF) and its receptor mRNAs increases in different brain structures after convulsive seizures. The physiological significance of this increase was investigated by chronic intrahippocampal perfusion of BDNF in the model of dorsal hippocampal kindling in the rat. A 7 day perfusion of BDNF, in the region of the stimulating electrode, blocked the development of kindling during the perfusion period and for the following 15 days. These results provide in vivo evidence for a protective role of BDNF in the regulation of plasticity involved in epileptogenesis in adult brain. FAU - Larmet, Y AU - Larmet Y AD - Unite INSERM 398, Universite Louis Pasteur, Strasbourg, France. FAU - Reibel, S AU - Reibel S FAU - Carnahan, J AU - Carnahan J FAU - Nawa, H AU - Nawa H FAU - Marescaux, C AU - Marescaux C FAU - Depaulis, A AU - Depaulis A LA - eng PT - Journal Article PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Nerve Tissue Proteins) RN - 0 (Neuroprotective Agents) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor MH - Electric Stimulation MH - Epilepsy/*prevention & control MH - Hippocampus/*drug effects MH - Kindling, Neurologic/*drug effects MH - Male MH - Nerve Growth Factors/*pharmacology MH - Nerve Tissue Proteins/*pharmacology MH - Neuroprotective Agents/*pharmacology MH - Perfusion MH - Rats MH - Rats, Wistar EDAT- 1995/10/02 00:00 MHDA- 1995/10/02 00:01 CRDT- 1995/10/02 00:00 PHST- 1995/10/02 00:00 [pubmed] PHST- 1995/10/02 00:01 [medline] PHST- 1995/10/02 00:00 [entrez] AID - 10.1097/00001756-199510020-00027 [doi] PST - ppublish SO - Neuroreport. 1995 Oct 2;6(14):1937-41. doi: 10.1097/00001756-199510020-00027.