PMID- 8548797
OWN - NLM
STAT- MEDLINE
DCOM- 19960221
LR  - 20240109
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 83
IP  - 7
DP  - 1995 Dec 29
TI  - Virus induction of human IFN beta gene expression requires the assembly of an 
      enhanceosome.
PG  - 1091-100
AB  - We present evidence that transcriptional activation of the human interferon-beta 
      (IFN beta) gene requires the assembly of a higher order transcription enhancer 
      complex (enhanceosome). This multicomponent complex includes at least three 
      distinct transcription factors and the high mobility group protein HMG I(Y). Both 
      the in vitro assembly and in vivo transcriptional activity of this complex 
      require a precise helical relationship between individual transcription 
      factor-binding sites. In addition, HMG I(Y), which binds specifically to three 
      sites within the enhancer, promotes cooperative binding of transcriptional 
      factors in vitro and is required for transcriptional synergy between these 
      factors in vivo. Thus, HMG I(Y) plays an essential role in the assembly and 
      function of the IFN beta gene enhanceosome.
FAU - Thanos, D
AU  - Thanos D
AD  - Department of Molecular and Cellular Biology, Harvard University, Cambridge, 
      Massachusetts 02138, USA.
FAU - Maniatis, T
AU  - Maniatis T
LA  - eng
GR  - AI20642/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Transcription Factors)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Animals
MH  - Binding Sites/physiology
MH  - Drosophila
MH  - Enhancer Elements, Genetic/*genetics
MH  - Gene Expression Regulation, Viral/genetics
MH  - HeLa Cells/physiology
MH  - High Mobility Group Proteins/genetics
MH  - Humans
MH  - Interferon-beta/*genetics
MH  - Promoter Regions, Genetic/genetics
MH  - Sensitivity and Specificity
MH  - Transcription Factors/genetics/metabolism
MH  - Transfection
MH  - Y Chromosome/genetics
EDAT- 1995/12/29 00:00
MHDA- 1995/12/29 00:01
CRDT- 1995/12/29 00:00
PHST- 1995/12/29 00:00 [pubmed]
PHST- 1995/12/29 00:01 [medline]
PHST- 1995/12/29 00:00 [entrez]
AID - 0092-8674(95)90136-1 [pii]
AID - 10.1016/0092-8674(95)90136-1 [doi]
PST - ppublish
SO  - Cell. 1995 Dec 29;83(7):1091-100. doi: 10.1016/0092-8674(95)90136-1.