PMID- 8553502
OWN - NLM
STAT- MEDLINE
DCOM- 19960220
LR  - 20190830
IS  - 0301-5629 (Print)
IS  - 0301-5629 (Linking)
VI  - 21
IP  - 8
DP  - 1995
TI  - Hematologic and growth-related effects of frequent prenatal ultrasound exposure 
      in the long-tailed macaque (Macaca fascicularis).
PG  - 1073-81
AB  - Prior investigations have shown that reduced birth weights and transient 
      neutropenias result from frequent exposure of monkey fetuses to ultrasound. To 
      further explore these findings, 26 animals were studied (16 exposed, 10 controls; 
      "triple mode"; ATL Ultramark 9 with HDI; ISPTAd approximately 645 to 714 mW/cm2). 
      Exposures were performed daily for 5 days each week from gestational days (GD) 21 
      to 35 (5 min), three times weekly from GD 36 to 60 (5 min), then weekly from GD 
      61 to 153 +/- 1 (10 min). Fetal blood samples (FBS) were collected for complete 
      blood counts (CBCs), hematopoietic progenitor assay, circulating insulin-like 
      growth factors (IGF-I, IGF-II) and binding proteins (IGFBP-3) (GD 120, 140, 153 
      +/- 1). Animals were delivered by Cesarean section at term (GD 153 +/- 1), and 
      body weights, morphometrics, CBCs, and bone marrow aspirates assessed at delivery 
      and postnatally for 3 months. Fetal neutropenias were noted in exposed animals in 
      addition to reduced circulating progenitors (colony forming 
      unit-granulocyte-macrophage [CFU-GM]). Growth of CFU-GM from bone marrow was 
      exuberant at term, whereas circulating levels were diminished comparable to 
      prenatal samples. Exposed animals were smaller at birth; marked reductions in 
      IGFBP-3 were noted prenatally. These data suggest that frequent prenatal 
      ultrasound exposure can transiently alter the neutrophil lineage, although these 
      findings may be the result of enhanced margination and organ sequestration. Data 
      also suggest that transient, altered growth patterns may be due to perturbations 
      of the IGF axis.
FAU - Tarantal, A F
AU  - Tarantal AF
AD  - California Regional Primate Research Center, University of California, Davis 
      95616-8542, USA.
FAU - Gargosky, S E
AU  - Gargosky SE
FAU - Ellis, D S
AU  - Ellis DS
FAU - O'Brien, W D Jr
AU  - O'Brien WD Jr
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
GR  - HD25528/HD/NICHD NIH HHS/United States
GR  - RR00169/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Blood Cell Count
MH  - Body Weight
MH  - Bone Marrow/diagnostic imaging
MH  - Bone Marrow Cells
MH  - Cell Lineage
MH  - Cesarean Section
MH  - *Embryonic and Fetal Development
MH  - Female
MH  - Fetal Blood/*diagnostic imaging
MH  - Gestational Age
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/blood
MH  - Growth
MH  - Hematopoietic Stem Cells/diagnostic imaging
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Insulin-Like Growth Factor II/analysis
MH  - Macaca fascicularis
MH  - Neutropenia/etiology
MH  - Pregnancy
MH  - Temperature
MH  - *Ultrasonography, Prenatal
EDAT- 1995/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 030156299500048V [pii]
AID - 10.1016/0301-5629(95)00048-v [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 1995;21(8):1073-81. doi: 10.1016/0301-5629(95)00048-v.