PMID- 8555377
OWN - NLM
STAT- MEDLINE
DCOM- 19960228
LR  - 20221207
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 38
IP  - 10
DP  - 1995 Nov 15
TI  - Plasma amino acid ratios related to brain serotonin synthesis in response to food 
      intake in bulimia nervosa.
PG  - 659-68
AB  - Fifteen bulimic women (BN) and 19 healthy female controls (CO) were studied. The 
      subjects were cross-over treated with either fluoxetine (FXT) or placebo during 4 
      days. They received, in randomized order, a breakfast containing pure 
      carbohydrate (CHO) or a protein-rich (PROT) breakfast following day 3 and 4 of 
      each treatment period. Twenty-nine different food items were offered for lunch. 
      The fasting serum glucose and insulin concentrations and the fasting plasma 
      tryptophan (Trp)/large neutral amino acid (LNAA) ratio were slightly higher in 
      BN. The changes of these metabolic parameters in response to a CHO or PROT 
      breakfast were similar in both groups. Across breakfast type, the plasma 
      (Trp)/(LNAA) ratio at 120 min after breakfast was higher in BN. Total caloric 
      intake at lunchtime was less in BN. In CO, less carbohydrate was selected at 
      lunchtime following the CHO breakfast, an effect that was abolished by FXT. 
      Breakfast type or FXT did not have any apparent effect on food intake at 
      lunchtime in BN. This might indicate that bulimic subjects are less sensitive to 
      serotoninergic stimuli than control subjects.
FAU - Pijl, H
AU  - Pijl H
AD  - Department of General Internal Medicine, University Hospital Leiden, The 
      Netherlands.
FAU - Cohen, A F
AU  - Cohen AF
FAU - Verkes, R J
AU  - Verkes RJ
FAU - Koppeschaar, H P
AU  - Koppeschaar HP
FAU - Iestra, J A
AU  - Iestra JA
FAU - Schoemaker, H C
AU  - Schoemaker HC
FAU - Frolich, M
AU  - Frolich M
FAU - Onkenhout, W
AU  - Onkenhout W
FAU - Meinders, A E
AU  - Meinders AE
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Insulin)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Adult
MH  - Amino Acids/*blood
MH  - Analysis of Variance
MH  - Blood Glucose/drug effects/metabolism
MH  - Brain/*metabolism
MH  - Bulimia/*metabolism
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage/pharmacology
MH  - Dietary Proteins/administration & dosage/pharmacology
MH  - Double-Blind Method
MH  - Energy Intake
MH  - Feeding Behavior/*drug effects
MH  - Female
MH  - Fluoxetine/*pharmacology
MH  - Humans
MH  - Insulin/blood
MH  - Serotonin/*biosynthesis
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
MH  - Tryptophan/blood
EDAT- 1995/11/15 00:00
MHDA- 1995/11/15 00:01
CRDT- 1995/11/15 00:00
PHST- 1995/11/15 00:00 [pubmed]
PHST- 1995/11/15 00:01 [medline]
PHST- 1995/11/15 00:00 [entrez]
AID - 0006-3223(95)00043-7 [pii]
AID - 10.1016/0006-3223(95)00043-7 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1995 Nov 15;38(10):659-68. doi: 10.1016/0006-3223(95)00043-7.