PMID- 8555598
OWN - NLM
STAT- MEDLINE
DCOM- 19960226
LR  - 20190914
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 40
IP  - 3
DP  - 1994 Jul-Sep
TI  - Formal analytical solution to a regional blood flow and diffusion based urea 
      kinetic model.
PG  - M667-73
AB  - At the beginning of hemodialysis (HD), urea in arterial blood drops rapidly, 
      whereas a pronounced postdialytic urea rebound (PDUR) can be observed when HD is 
      discontinued. In a new approach to this observation, the authors suggest that 
      solute flux from remote body compartments to the dialyzer is governed by 1) 
      diffusion of solutes from the tissue to the blood perfusing the tissue, and 2) by 
      regional blood flow distribution, cardiopulmonary recirculation, and access 
      recirculation, respectively. These concepts were incorporated into a variable 
      volume, two compartment model that could be treated as an eigenvalue problem and 
      solved analytically. The resulting equations were used to model intradialytic and 
      postdialytic urea profiles with the help of a commercial spreadsheet program. The 
      significance of hemodynamic model parameters such as cardiac output (CO) and 
      regional blood flow distribution on PDUR was modeled in simulation runs, where 
      PDUR increased from 5% to 15% when CO fell from 7 to 3 l/min with standard 
      treatment parameters (t = 3h, KD = 0.3 l/min, V = 35l, UFV = 2.8l, fQHFS = 0.8, 
      QAc = 0.8l/min). Thus, this urea kinetic model establishes a previously missing 
      link between hemodynamics and solute removal.
FAU - Schneditz, D
AU  - Schneditz D
AD  - Department of Physiology, Karl-franzens University Graz, Austria.
FAU - Daugirdas, J T
AU  - Daugirdas JT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Biological Transport, Active
MH  - Cardiac Output
MH  - Diffusion
MH  - Hemodynamics
MH  - Humans
MH  - Kinetics
MH  - *Models, Biological
MH  - Models, Cardiovascular
MH  - Regional Blood Flow
MH  - *Renal Dialysis
MH  - Urea/*blood/pharmacokinetics
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1097/00002480-199407000-00082 [doi]
PST - ppublish
SO  - ASAIO J. 1994 Jul-Sep;40(3):M667-73. doi: 10.1097/00002480-199407000-00082.