PMID- 8555700
OWN - NLM
STAT- MEDLINE
DCOM- 19960227
LR  - 20190920
IS  - 0941-1291 (Print)
IS  - 0941-1291 (Linking)
VI  - 25
IP  - 9
DP  - 1995
TI  - Use of a pericardial fat pad flap for preventing bronchopleural fistula: an 
      experimental study focusing on the angiogenesis and cytokine production of the 
      fat pad.
PG  - 811-5
AB  - An experimental study was conducted to determine whether pericardial fat tissue 
      could induce neovascularization and produce cytokines related to tissue repair. 
      Neovascularization was examined using chick chorioallantoic membranes. Pieces of 
      pericardial fat tissue, omentum, and intercostal muscle were individually placed 
      on a number of chorioallantoic membranes and neovascularization induced by each 
      material was assayed 6 days after the implantation. The intensity of 
      neovascularization was in the order of pericardial fat > or = omentum > muscle. 
      Cytokines, such as interleukin 1 (IL-1) alpha and beta, tumor necrosis 
      factor-alpha (TNF alpha), interferon-gamma (IFN-gamma), and interleukin 6 (IL-6) 
      were assayed in a culture supernatant of pericardial fat tissue. The latter was 
      obtained 24 h after the addition of lipopolysaccharide (LPS) following various 
      incubation times. All cytokines other than IFN gamma are known to play a part in 
      tissue repair, whereas IFN gamma is negatively related to tissue repair because 
      it inhibits fibroblast growth. The pericardial fat tissue incubated with LPS 
      produced a certain amount of IL-1 on day 1, and TNF alpha on days 1 and 8, 
      whereafter these values decreased to an undetectable level. Irrespective of the 
      addition of LPS, a large amount of IL-6 was observed in the supernatant of 
      pericardial fat tissue and it was detectable until day 29. On the contrary, INF 
      gamma was not detected at any assay time. These observations suggest that a 
      pericardial fat pad flap could possibly be beneficial in the prevention of 
      bronchopleural fistula after pulmonary resection.
FAU - Ichinose, Y
AU  - Ichinose Y
AD  - Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
FAU - Asoh, H
AU  - Asoh H
FAU - Yano, T
AU  - Yano T
FAU - Yokoyama, H
AU  - Yokoyama H
FAU - Inoue, T
AU  - Inoue T
FAU - Tayama, K
AU  - Tayama K
FAU - Ueda, T
AU  - Ueda T
FAU - Takai, E
AU  - Takai E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Cytokines)
SB  - IM
MH  - Adipose Tissue/blood supply/*transplantation
MH  - Animals
MH  - Bronchial Fistula/pathology/*prevention & control
MH  - Chick Embryo
MH  - Culture Techniques
MH  - Cytokines/*metabolism
MH  - Fistula/pathology/*prevention & control
MH  - Humans
MH  - Neovascularization, Physiologic/*physiology
MH  - Pericardium/*transplantation
MH  - Pleural Diseases/pathology/*prevention & control
MH  - *Pneumonectomy
MH  - Postoperative Complications/pathology/prevention & control
MH  - Wound Healing/physiology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF00311458 [doi]
PST - ppublish
SO  - Surg Today. 1995;25(9):811-5. doi: 10.1007/BF00311458.