PMID- 8556830
OWN - NLM
STAT- MEDLINE
DCOM- 19960228
LR  - 20061115
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 44
IP  - 3
DP  - 1995 Sep
TI  - Monocyte chemoattractant protein-1 in normal and diseased human kidneys: an 
      immunohistochemical analysis.
PG  - 148-55
AB  - We conducted an immunohistochemical analysis to investigate the presence of 
      monocyte chemoattractant protein-1 (MCP-1) in normal and diseased human kidneys 
      and the correlation with infiltration of macrophages. A total of 50 renal 
      biopsies were classified according to pathologic diagnosis. The distribution as 
      well as the intensity of MCP-1 staining, and infiltration by CD68+ macrophages 
      were evaluated in diseased versus normal kidneys. Weak staining of MCP-1 was 
      detected in normal renal tissue, especially in tubular epithelial cells. 
      Significant alterations in MCP-1 staining were observed in a number of diseases, 
      in which the intensity of MCP-1 staining rather than the distribution of 
      MCP-1-positive cells was higher. In membranous nephropathy, IgA nephropathy, and 
      glomerulosclerosis, an association was found between the intensity of MCP-1 
      staining in tubular epithelial cells and interstitial infiltration of 
      macrophages. The glomeruli in membranous nephropathy showed a stronger intensity 
      of MCP-1 staining particularly in the glomerular visceral epithelial cells. The 
      glomerular MCP-1 staining did not correlate significantly with the number of 
      macrophages in the glomeruli. In conclusion, we describe increased cellular 
      staining for MCP-1 in diseased human renal tissue, especially by tubular 
      epithelial cells. Our observations suggest, complementary to in vitro and in vivo 
      observations made by us and others, that specific roles may be played by MCP-1 in 
      physiological and inflammatory processes in the kidney.
FAU - Prodjosudjadi, W
AU  - Prodjosudjadi W
AD  - Department of Nephrology, University Hospital Leiden, The Netherlands.
FAU - Gerritsma, J S
AU  - Gerritsma JS
FAU - van Es, L A
AU  - van Es LA
FAU - Daha, M R
AU  - Daha MR
FAU - Bruijn, J A
AU  - Bruijn JA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Biopsy
MH  - Chemokine CCL2/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Diseases/*metabolism/pathology
MH  - Macrophages/pathology
MH  - Sensitivity and Specificity
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1995 Sep;44(3):148-55.