PMID- 8556832
OWN - NLM
STAT- MEDLINE
DCOM- 19960228
LR  - 20161123
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 44
IP  - 3
DP  - 1995 Sep
TI  - Isosorbide 5 mononitrate administration increases nitric oxide blood levels and 
      reduces proteinuria in IgA glomerulonephritis patients with abnormal urinary 
      endothelin/cyclic GMP ratio.
PG  - 163-9
AB  - An endothelin urinary hyperexcretion, which is not counterbalanced by an adequate 
      increase in cGMP biosynthesis, was previously detected in some patients with IgA 
      Nephropathy (IgAN). Since this imbalance might potentiate local ET1-mediated 
      hemodynamics effects, 9 IgAN patients with an increased (> or = 0.1) urinary 
      ET1/cGMP ratio (group 1) and 5 IgAN patients with comparable renal function and 
      reduced ET1/cGMP ratio (group 2) were given standard doses of isosorbide 5 
      mononitrate (as a nitric oxide source). Blood nitric oxide (NO) levels, as 
      detected by electron paramagnetic resonance, significantly increased after 
      isosorbide administration (p < 0.01) and decreased after drug discontinuation in 
      both groups. Nitric oxide levels were significantly related with those of the 
      effective renal plasma flow (p < 0.02), but not with the glomerular filtration 
      rate. Proteinuria levels significantly decreased after drug administration (p < 
      0.009) in group 1 and returned to baseline levels thereafter, except two cases 
      showing persisting low levels. Values of filtration fraction in the same group 
      decreased after iso5M administration (p < 0.02 compared to basal levels). These 
      results may possibly be related to the counterbalancing effects of nitric oxide 
      on endothelin-mediated mesangial contraction.
FAU - Roccatello, D
AU  - Roccatello D
AD  - Istituto di Nefrourologia, Universita di Torino, Italy.
FAU - Mengozzi, G
AU  - Mengozzi G
FAU - Ferro, M
AU  - Ferro M
FAU - Cesano, G
AU  - Cesano G
FAU - Polloni, R
AU  - Polloni R
FAU - Mosso, R
AU  - Mosso R
FAU - Bonetti, G
AU  - Bonetti G
FAU - Inconis, T
AU  - Inconis T
FAU - Paradisi, L
AU  - Paradisi L
FAU - Sena, L M
AU  - Sena LM
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Endothelins)
RN  - 0 (Vasodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - H2D2X058MU (Cyclic GMP)
RN  - IA7306519N (Isosorbide Dinitrate)
RN  - LX1OH63030 (isosorbide-5-mononitrate)
SB  - IM
MH  - Adult
MH  - Blood Pressure/drug effects
MH  - Cyclic GMP/*urine
MH  - Electron Spin Resonance Spectroscopy
MH  - Endothelins/*urine
MH  - Female
MH  - Glomerulonephritis, IGA/complications/*drug therapy/metabolism
MH  - Humans
MH  - Isosorbide Dinitrate/*analogs & derivatives/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*blood
MH  - Proteinuria/*drug therapy/etiology/metabolism
MH  - Vasodilator Agents/*therapeutic use
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1995 Sep;44(3):163-9.