PMID- 8558854
OWN - NLM
STAT- MEDLINE
DCOM- 19960227
LR  - 20061115
IS  - 0023-6837 (Print)
IS  - 0023-6837 (Linking)
VI  - 73
IP  - 6
DP  - 1995 Dec
TI  - High lipid levels in very low density lipoprotein and intermediate density 
      lipoprotein may cause proteinuria and glomerulosclerosis in aging female 
      analbuminemic rats.
PG  - 912-21
AB  - BACKGROUND: Male rats are generally more prone to developing renal disease than 
      female rats. However, female Nagase analbuminemic rats (NAR) are profoundly 
      hyperlipidemic and develop proteinuria and glomerulosclerosis after 
      uninephrectomy. Male NAR are less hyperlipidemic and are resistant to developing 
      renal damage after uninephrectomy. Ovariectomy markedly decreases hepatic 
      triglyceride secretion and plasma triglyceride levels in the female NAR. 
      EXPERIMENTAL DESIGN: In this study, we investigated the relationship between 
      plasma lipids and lipoprotein composition as well as the development of 
      proteinuria, glomerular apolipoprotein and lipid deposition, and 
      glomerulosclerosis in aging female and male analbuminemic rats. We also studied 
      whether ovariectomy in female NAR at an early age would protect their renal 
      function in old age. RESULTS: Aging hyperlipidemic female NAR with high 
      triglyceride and cholesterol levels in very low density lipoprotein (VLDL) and 
      intermediate density lipoprotein (IDL) were found to develop spontaneous 
      proteinuria at 9 months of age. Glomerular lipid deposition and 
      glomerulosclerosis were observed at 18 months of age. In male NAR that had lower 
      lipid levels in VLDL and IDL, only mild proteinuria and no glomerular lipid 
      deposition or glomerulosclerosis were observed up to the age of 22 months. 
      Concurrently ovariectomized NAR demonstrated profound and persistent decreases in 
      triglyceride and cholesterol content of VLDL and IDL as well as total plasma 
      triglycerides, without much change in LDL, high density lipoprotein, total plasma 
      cholesterol, or apolipoprotein B, and they remained completely free of 
      proteinuria and glomerulosclerosis. Apolipoprotein B deposition in glomeruli was 
      not different in the oldest female, male, or ovariectomized NAR. No important 
      differences were observed in glomerular diameter between the three different 
      groups up to the age of 1 year. CONCLUSIONS: These findings point to an important 
      role of elevated lipid content of the triglyceride-rich lipoproteins VLDL and IDL 
      in the pathogenesis of proteinuria and glomerulosclerosis in the female NAR.
FAU - Joles, J A
AU  - Joles JA
AD  - Department of Nephrology and Hypertension, Faculty of Medicine, Utrecht 
      University, The Netherlands.
FAU - van Goor, H
AU  - van Goor H
FAU - van der Horst, M L
AU  - van der Horst ML
FAU - van Tol, A
AU  - van Tol A
FAU - Elema, J D
AU  - Elema JD
FAU - Koomans, H A
AU  - Koomans HA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Invest
JT  - Laboratory investigation; a journal of technical methods and pathology
JID - 0376617
RN  - 0 (Blood Proteins)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Lipoproteins, IDL)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Blood Pressure
MH  - Blood Proteins/analysis
MH  - Female
MH  - Glomerulosclerosis, Focal Segmental/*etiology
MH  - Kidney Glomerulus/metabolism/pathology
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Lipoproteins/*blood
MH  - Lipoproteins, IDL
MH  - Lipoproteins, VLDL/*blood
MH  - Male
MH  - Proteinuria/*etiology
MH  - Rats
MH  - Serum Albumin/*deficiency
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PST - ppublish
SO  - Lab Invest. 1995 Dec;73(6):912-21.