PMID- 8559376
OWN - NLM
STAT- MEDLINE
DCOM- 19960223
LR  - 20220408
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 46
IP  - 1
DP  - 1996 Jan
TI  - Low-grade oligodendroglioma responds to chemotherapy.
PG  - 203-7
AB  - We administered chemotherapy in standard and intensified formulations of 
      procarbazine, lomustine (CCNU), and vincristine to nine symptomatic patients with 
      low-grade oligodendroglioma. Eight patients were treated with chemotherapy at 
      presentation and one was treated for a recurrence after radiotherapy had failed. 
      All patients improved by clinical or MRI criteria, or both. No patient 
      deteriorated while in therapy and the responses were sustained without 
      radiotherapy for a median of 35 months (range, 22-45) in all surviving patients 
      treated at presentation. Chemotherapy was well tolerated; all patients developed 
      myelosuppression, but only those receiving the intensified regimen required dose 
      reduction or premature discontinuation of treatment. As with recurrent and 
      anaplastic oligodendroglioma, low-grade oligodendroglioma responds to 
      chemotherapy.
FAU - Mason, W P
AU  - Mason WP
AD  - Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 
      10021, USA.
FAU - Krol, G S
AU  - Krol GS
FAU - DeAngelis, L M
AU  - DeAngelis LM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 35S93Y190K (Procarbazine)
RN  - 5J49Q6B70F (Vincristine)
RN  - 7BRF0Z81KG (Lomustine)
RN  - PCV protocol
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Brain Neoplasms/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Lomustine/administration & dosage
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oligodendroglioma/*drug therapy/pathology
MH  - Procarbazine/administration & dosage
MH  - Vincristine/administration & dosage
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1212/wnl.46.1.203 [doi]
PST - ppublish
SO  - Neurology. 1996 Jan;46(1):203-7. doi: 10.1212/wnl.46.1.203.