PMID- 8560405
OWN - NLM
STAT- MEDLINE
DCOM- 19960228
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 74
IP  - 4
DP  - 1995 Oct
TI  - Influence of various heparin preparations on lipoproteins in hemodialysis 
      patients: a multicentre study.
PG  - 1025-8
AB  - Recent studies have indicated controversial effects of low molecular weight 
      heparin (LMWH) on lipid metabolism in patients on chronic hemodialysis as 
      compared to unfractionated heparin (UFH). We therefore conducted a 
      cross-sectional multicentre study comparing 153 patients treated with LMWH and 
      153 patients with UFH, matched for sex, age and diabetes mellitus. Both groups 
      have been treated with LMWH or UFH for six months or longer (14.9 vs. 23.4 
      months). We observed no differences between the UFH and LMWH treatment groups for 
      total cholesterol, LDL cholesterol, triglycerides, apoB, apoA-IV or Lp(a). The 
      only significant differences were seen for HDL cholesterol and the corresponding 
      apolipoprotein apoA-I, which were significantly higher in the UFH group (HDL 
      cholesterol: 0.97 +/- 0.35 mM/l vs. 0.87 +/- 0.37 mM/l, p < 0.05; apoA-I 1.23 +/- 
      0.27 g/l vs. 1.15 +/- 0.27 g/l, p < 0.05). We conclude that the results of 
      studies investigating the influence of LMWH on lipid metabolism are as 
      heterogeneous as the substances themselves. This challenges the beneficial 
      influence supposedly had by LMWH preparations on lipid metabolism.
FAU - Kronenberg, F
AU  - Kronenberg F
AD  - Institute of Medical Biology and Human Genetics, University of Innsbruck, 
      Austria.
FAU - Konig, P
AU  - Konig P
FAU - Neyer, U
AU  - Neyer U
FAU - Auinger, M
AU  - Auinger M
FAU - Pribasnig, A
AU  - Pribasnig A
FAU - Meisl, T
AU  - Meisl T
FAU - Pinter, G
AU  - Pinter G
FAU - Dieplinger, H
AU  - Dieplinger H
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Lipoproteins)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anticoagulants/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/blood/therapy
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Lipoproteins/*blood
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1995 Oct;74(4):1025-8.