PMID- 8560541
OWN - NLM
STAT- MEDLINE
DCOM- 19960227
LR  - 20190512
IS  - 0035-9203 (Print)
IS  - 0035-9203 (Linking)
VI  - 89
IP  - 5
DP  - 1995 Sep-Oct
TI  - Nutritional status and the IgE response against Ascaris lumbricoides in children 
      from a tropical slum.
PG  - 562-5
AB  - Helminthic infection can stimulate the interleukin-4 (IL-4)-dependent polyclonal 
      synthesis of immunoglobulin E (IgE) in children endemically exposed to these 
      parasites. As such children are also frequently at nutritional risk, in this 
      study we considered the possible influence of malnutrition on serum IL-4 levels 
      and the IgE response in helminthic infection. We evaluated 85 Ascaris-infected 
      children living in an urban slum area of Caracas, Venezuela, and found that the 
      serum levels of IL-4 and total IgE were significantly higher in malnourished 
      children than in their well nourished counterparts. In contrast, the specific 
      anti-Ascaris IgE antibody response was significantly lower in the malnourished 
      group. After anthelmintic treatment of the children, the total serum IgE and IL-4 
      levels decreased significantly in the well nourished group, while the specific 
      anti-Ascaris IgE antibody response increased. No significant change was detected, 
      however, in the malnourished group. Our results suggested that malnutrition 
      potentiates the polyclonal stimulation of IgE synthesis induced by helminths. As 
      specific IgE antibody has been implicated in the resistance to helminthic 
      infection, and the polyclonal stimulus diminishes this response, these factors 
      may increase the susceptibility of malnourished children to such parasites.
FAU - Hagel, I
AU  - Hagel I
AD  - Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, 
      Caracas, Venezuela.
FAU - Lynch, N R
AU  - Lynch NR
FAU - Di Prisco, M C
AU  - Di Prisco MC
FAU - Sanchez, J
AU  - Sanchez J
FAU - Perez, M
AU  - Perez M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Anthelmintics)
RN  - 0 (Antibodies, Helminth)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Anthelmintics/therapeutic use
MH  - Antibodies, Helminth/*biosynthesis
MH  - Antibody Specificity
MH  - Ascariasis/blood/drug therapy/*immunology
MH  - Ascaris lumbricoides/*immunology
MH  - Child
MH  - Feces/parasitology
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Interleukin-4/blood
MH  - Nutrition Disorders/*immunology/parasitology
MH  - Nutritional Status
MH  - Parasite Egg Count
MH  - Poverty Areas
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1016/0035-9203(95)90109-4 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):562-5. doi: 
      10.1016/0035-9203(95)90109-4.