PMID- 8561276
OWN - NLM
STAT- MEDLINE
DCOM- 19960226
LR  - 20190825
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 19
IP  - 5
DP  - 1995 Oct
TI  - Family history of alcoholism and the mediation of alcohol intake by catalase: 
      further evidence for catalase as a marker of the propensity to ingest alcohol.
PG  - 1096-104
AB  - Earlier studies have suggested that catalase activity (CA) may represent a 
      biological marker of alcohol intake in animals and in humans. An initial study 
      was designed to rule out the possibility that CA is induced as a function of 
      acute alcohol intake. Subjects (n = 80) were presented with either an alcohol 
      (0.5 g/kg of body weight) or control solution, and asked to provide four 
      100-microliters blood samples at 0.0, 0.5, 2.0, and 24.0 hr. Results showed no 
      differences in CA between individuals who had received alcohol, and controls, 
      even when the effects of previous drinking history were covaried out. This lack 
      of effect of acute alcohol intake on the possible induction of CA further 
      supported the notion that CA may be a viable marker of alcohol intake, rather 
      than the converse. In the second study, the relation between CA and alcohol 
      intake was investigated in individuals with a family history (FH) of alcoholism 
      (FH+), and in those without a family history of alcoholism (FH-). Subjects (n = 
      607) completed the Michigan Alcoholism Screening Questionnaire, the MacAndrew 
      Scale, and the Concordia University Alcohol Screening Questionnaire; answered 
      questions concerning their FH for alcoholism; and provided a 100-microliters 
      blood sample. Results showed that FH+ individuals had higher mean CA compared 
      with FH- individuals. When individuals with FH+ were compared with those with 
      FH-, differences in the pattern of relation between CA and alcohol intake were 
      observed. Although a significant relation between CA and alcohol intake was 
      obtained for both FH- and FH+ individuals, this relation was significantly higher 
      (p < 0.001) for individuals with FH+.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Koechling, U M
AU  - Koechling UM
AD  - Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, 
      Quebec, Canada.
FAU - Amit, Z
AU  - Amit Z
FAU - Negrete, J C
AU  - Negrete JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Genetic Markers)
RN  - EC 1.11.1.6 (Catalase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/genetics
MH  - Alcoholism/enzymology/*genetics
MH  - Catalase/blood/*genetics
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Risk Factors
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1111/j.1530-0277.1995.tb01586.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 1995 Oct;19(5):1096-104. doi: 
      10.1111/j.1530-0277.1995.tb01586.x.