PMID- 8562345
OWN - NLM
STAT- MEDLINE
DCOM- 19960305
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 73
IP  - 3
DP  - 1996 Feb
TI  - Hepatocyte growth factor/scatter factor is present in most pleural effusion 
      fluids from cancer patients.
PG  - 377-81
AB  - Pleural effusion samples were obtained from 55 patients with malignant disease, 
      including patients with primary lung cancers and those with a variety of other 
      tumours metastatic to the pleura. The effusions were assayed for the presence of 
      hepatocyte growth factor/scatter factor (HGF/SF), by both ELISA and bioassay. The 
      presence of malignant cells in the effusions was also assessed. Detectable 
      amounts of the factor, as judged by both criteria, were found in over 90% of all 
      the effusions, including those from patients with a wide variety of carcinomas 
      and also lymphomas. A wide range of HGF/SF levels were found for all tumour 
      classes, some effusions containing high levels above 4 ng ml-1. It is concluded 
      that tumours within the pleura and adjacent lung tissue are usually exposed to 
      biologically significant levels of HGF/SF.
FAU - Eagles, G
AU  - Eagles G
AD  - School of Biology, University of East Anglia, Norwich, UK.
FAU - Warn, A
AU  - Warn A
FAU - Ball, R Y
AU  - Ball RY
FAU - Baillie-Johnson, H
AU  - Baillie-Johnson H
FAU - Arakaki, N
AU  - Arakaki N
FAU - Daikuhara, Y
AU  - Daikuhara Y
FAU - Warn, R M
AU  - Warn RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Carcinoma/*metabolism
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Leukemia/*metabolism
MH  - Lymphoma/*metabolism
MH  - Pleural Effusion/*metabolism
MH  - Sarcoma/*metabolism
PMC - PMC2074438
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1038/bjc.1996.64 [doi]
PST - ppublish
SO  - Br J Cancer. 1996 Feb;73(3):377-81. doi: 10.1038/bjc.1996.64.