PMID- 8563033
OWN - NLM
STAT- MEDLINE
DCOM- 19960307
LR  - 20191101
IS  - 1056-8719 (Print)
IS  - 1056-8719 (Linking)
VI  - 34
IP  - 2
DP  - 1995 Oct
TI  - Analysis of the enantiomers of 3,4-methylenedioxy-N-ethylamphetamine (MDE, "Eve") 
      and its metabolite 3,4-methylenedioxyamphetamine (MDA) in rat brain.
PG  - 117-23
AB  - The methylenedioxy analogues of amphetamine are used recreationally despite 
      concerns raised regarding potential neurotoxicity of the parent compounds and a 
      number of metabolites. Much has been written regarding 
      3,4-methylenedioxymethamphetamine (MDMA; 3,4-methylenedioxy-N-ethylamphetamine 
      (MDE; "Eve"), despite recent reports indicating the abuse of this drug and its 
      potentially serious side effects. An assay procedure was developed for the 
      simultaneous quantitation of both enantiomers of MDE and its metabolite MDA; the 
      method involves derivatization with an optically pure reagent and analysis on a 
      gas chromatograph equipped with a capillary column and a nitrogen-phosphorus 
      detector. Brain levels of the enantiomers of MDE and MDA were examined in the rat 
      at different time periods after acute i.p. injections of racemic MDE and the 
      results were compared with levels of MDMA and MDA obtained after i.p. injection 
      of MDMA in a previous study from our laboratories. The levels of the enantiomers 
      of MDE and MDA achieved at 1, 4, and 8 hr were lower than in the case of MDMA. 
      Stereoselective differences in brain levels of enantiomers of the parent drug and 
      metabolite were much less marked with MDE than with MDMA, but where these small 
      differences did exist in the case of MDE, the (R)-(-) vs (S)-(+) relationship was 
      opposite to that reported for MDMA.
FAU - Hegadoren, K M
AU  - Hegadoren KM
AD  - Department of Psychiatry, University of Alberta, Edmonton, Canada.
FAU - Baker, G B
AU  - Baker GB
FAU - Coutts, R T
AU  - Coutts RT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
RN  - 0 (Designer Drugs)
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/metabolism/*toxicity
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Brain Chemistry
MH  - Chromatography, Gas
MH  - Designer Drugs/administration & dosage/metabolism/*toxicity
MH  - Hallucinogens/toxicity
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereoisomerism
MH  - Structure-Activity Relationship
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 1056-8719(95)00045-J [pii]
AID - 10.1016/1056-8719(95)00045-j [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 1995 Oct;34(2):117-23. doi: 
      10.1016/1056-8719(95)00045-j.