PMID- 8565807
OWN - NLM
STAT- MEDLINE
DCOM- 19960301
LR  - 20071115
IS  - 0012-0472 (Print)
IS  - 0012-0472 (Linking)
VI  - 121
IP  - 1-2
DP  - 1996 Jan 5
TI  - [Thromboendarterectomy in chronic thromboembolic pulmonary hypertension. 
      Hemodynamics and right-heart function over the long term].
PG  - 9-15
AB  - OBJECTIVE: To find out whether pulmonary thromboendarterectomy (PTE) can achieve 
      lasting reduction of pulmonary vascular resistance in patients with pulmonary 
      arterial hypertension due to chronic thromboembolism. PATIENTS AND METHODS: 45 
      patients (25 women, 20 men; mean age 45 +/- 24 [19-67] years) were 
      re-investigated a mean of 21 (13-32) months after successful PTE. Two patients 
      had then been in New York Heart Association (NYHA) stage II, 26 in stage III, and 
      17 in stage IV. In addition to clinical examination and chest radiogram 36 
      patients had right heart catheterization, 28 pulmonary angiography and 44 
      echocardiography. RESULTS: Definite improvement of symptoms had occurred in all. 
      34 were now in NYHA stage I, nine in stage II, and two in stage III. The 
      pulmonary vascular resistance was significantly lower than before and immediately 
      after PTE (pre-PTE: 1052 +/- 472 dyn.s.cm-5; post-PTE: 293 +/- 175 dyn.s.cm-5; at 
      follow-up: 187 +/- 92 dyn.s.cm-5; P < 0.001 for follow-up vs pre-PTE; P < 0.05 
      for follow-up vs post-PTE). Correspondingly, cardiac index had significantly 
      increased (3.0 +/- 0.5 vs 2.0 +/- 0.7 l/min.m2; P < 0.001). Radiological and 
      echocardiographic examinations showed a definite decrease in right ventricular 
      dimensions and improvement in right ventricular function. CONCLUSION: In patients 
      with pulmonary arterial hypertension due to chronic pulmonary thromboembolism PTE 
      can achieve a reduction in pulmonary vascular resistance with lasting improvement 
      in right heart function and clinical symptoms.
FAU - Mayer, E
AU  - Mayer E
AD  - Klinik fur Herz-, Thorax- und Gefasschirurgie, Universitat Mainz.
FAU - Dahm, M
AU  - Dahm M
FAU - Hake, U
AU  - Hake U
FAU - Schmid, F X
AU  - Schmid FX
FAU - Duber, C
AU  - Duber C
FAU - Kupferwasser, I
AU  - Kupferwasser I
FAU - Iversen, S
AU  - Iversen S
FAU - Oelert, H
AU  - Oelert H
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Thrombendarteriektomie bei chronischer thromboembolischer pulmonaler Hypertonie. 
      Hamodynamik und Rechtsherzfunktion im Langzeitverlauf.
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Atrial Function, Right
MH  - Chronic Disease
MH  - *Endarterectomy
MH  - Female
MH  - Follow-Up Studies
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*physiopathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Embolism/diagnosis/*physiopathology/*surgery
MH  - Retrospective Studies
MH  - Time Factors
MH  - Vena Cava Filters
MH  - *Ventricular Function, Right
EDAT- 1996/01/05 00:00
MHDA- 1996/01/05 00:01
CRDT- 1996/01/05 00:00
PHST- 1996/01/05 00:00 [pubmed]
PHST- 1996/01/05 00:01 [medline]
PHST- 1996/01/05 00:00 [entrez]
AID - 10.1055/s-2008-1042965 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 1996 Jan 5;121(1-2):9-15. doi: 10.1055/s-2008-1042965.