PMID- 8568372
OWN - NLM
STAT- MEDLINE
DCOM- 19960305
LR  - 20110727
IS  - 0021-5325 (Print)
IS  - 0021-5325 (Linking)
VI  - 69
IP  - 11
DP  - 1995 Nov
TI  - [Automatic determination for bone morphometry using a computed image analyzer].
PG  - 1170-81
AB  - An image analyzer which combines a digitizer and a computer is widely employed in 
      bone histomorphometrical evaluation. With this method, however, all regions of 
      determination are traced manually so that considerable time is consumed when many 
      preparations are measured. To resolve this problem, we have developed an 
      automatic program for rapid and quantitative measurement of many bone 
      histomorphometrical parameters using a computed color image analyzer. The bone 
      volume (BV), tissue volume (TV), osteoid surface (OS), and the bone surface (BS) 
      of rat tibia metaphysis were measured by this automatic method, and by the manual 
      method using an image analyzer. The correlation coefficient between both methods 
      in measuring BV/TV was 0.98 and in measuring OS/BS was 0.96. The reproducibility 
      and accuracy of both methods for these parameters were similar. The time required 
      for the automatic method was much shorter than that for the manual method. 
      Various parameters of the tibial metaphysis, lumbar vertebral body, and femoral 
      mid-diaphysis in ovariectomized rat (Fischer) measured by this method were in 
      good agreement with values reported previously.
FAU - Kobayashi, M
AU  - Kobayashi M
AD  - Department of Applied Drug Research, Eisai Co., Ltd., Japan.
FAU - Akiyama, Y
AU  - Akiyama Y
FAU - Tomiuga, T
AU  - Tomiuga T
FAU - Hara, K
AU  - Hara K
FAU - Nakamura, T
AU  - Nakamura T
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Seikeigeka Gakkai Zasshi
JT  - Nihon Seikeigeka Gakkai zasshi
JID - 0413716
SB  - IM
MH  - Animals
MH  - Bone and Bones/*anatomy & histology
MH  - Female
MH  - *Image Processing, Computer-Assisted
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reproducibility of Results
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Seikeigeka Gakkai Zasshi. 1995 Nov;69(11):1170-81.