PMID- 8571922
OWN - NLM
STAT- MEDLINE
DCOM- 19960301
LR  - 20131121
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 23
IP  - 3-4
DP  - 1995
TI  - The anti-inflammatory and anti-hyperuricemic effects of Chinese herbal formula 
      danggui-nian-tong-tang on acute gouty arthritis: a comparative study with 
      indomethacin and allopurinol.
PG  - 261-71
AB  - The traditional Chinese antirheumatic herb Danggui-Nian-Tong-Tang (DGNTT) was 
      studied comparatively with indomethacin and allopurinol to evaluate its 
      anti-inflammatory and antihyperuricemic effects in patients with gout. Results in 
      this study did not show any significant improvement in reducing the total number 
      of painful and swollen joints, articular index and pain score (P > 0.05) by 
      treatment with DGNTT. Unlike allopurinol, DGNTT did not lower the high serum 
      level of uric acid. In vitro study in rats showed that DGNTT significantly 
      inhibits the activity of beta-glucuronidase (P < 0.05) and lysozyme release (P < 
      0.01) from neutrophils. In conclusion, despite the effect of inhibition on enzyme 
      release from neutrophils, DGNTT is not effective in treating acute arthritis or 
      hyperuricemia.
FAU - Chou, C T
AU  - Chou CT
AD  - Rheumatology-Immunology Division, China Medical, College Hospital, Taichung, 
      Taiwan.
FAU - Kuo, S C
AU  - Kuo SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 63CZ7GJN5I (Allopurinol)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allopurinol/*therapeutic use
MH  - Arthritis, Gouty/*drug therapy
MH  - Female
MH  - Humans
MH  - Indomethacin/*therapeutic use
MH  - Lymphocyte Activation
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - S0192415X95000316 [pii]
AID - 10.1142/S0192415X95000316 [doi]
PST - ppublish
SO  - Am J Chin Med. 1995;23(3-4):261-71. doi: 10.1142/S0192415X95000316.