PMID- 8572875
OWN - NLM
STAT- MEDLINE
DCOM- 19960304
LR  - 20131121
IS  - 0003-9683 (Print)
IS  - 0003-9683 (Linking)
VI  - 88
IP  - 8
DP  - 1995 Aug
TI  - [Absence of the effect of nitric oxide on pulmonary and systemic hypertension 
      induced by sino-aortic denervation].
PG  - 1209-12
AB  - Inhaled nitric oxide, a selective pulmonary vasodilator, reverses hypoxic 
      pulmonary vasoconstriction and is an effective treatment in some cases of human 
      pulmonary hypertension. Localization of nitric oxide synthase had indicated a 
      neural role for nitric oxide. Thus, we studied the interactions between inhaled 
      nitric oxide and systemic and pulmonary vascular reactivity in acute neurogenic 
      hypertension. In 6 male beagle dogs (mean weight: 15 +/- 1 kg), anesthetized by 
      chloralose (8 cg/kg) and in spontaneous ventilation, the hemodynamic effects on 
      systemic and pulmonary circulation of inhaled nitric oxide (12 ppm) were studied 
      before and after acute sino-aortic denervation. The hemodynamic effects of 
      intravenous propranolol (300 micrograms/kg) were studied after denervation. Mean 
      arterial pressure (MAP), pulmonary capillary pressure (PCP), mean arterial 
      pulmonary pressure (MAPP), cardiac input (CI) and oxygen venous saturation (SvO2) 
      were measured. [table: see text] Sino-aortic denervation causes an acute and 
      transitory pulmonary hypertension due to a double mechanism: a post-capillary 
      hypertension (increase PCP) secondary to an increase left ventricular post-charge 
      by systemic hypertension and a precapillary hypertension. In fact, vascular 
      pulmonary resistances increase from 1.8 +/- 0.1 to 3.4 +/- 0.8 uW after 
      denervation (p < 0.05). Change in pulmonary vascular reactivity induced by 
      catecholamines is probably involved. Propranolol but not inhaled nitric oxide 
      reverse pulmonary hypertension due to sino-aortic denervation.
FAU - Galinier, M
AU  - Galinier M
AD  - Service de cardiologie et de chirurgie cardiovasculaire, Hopital Rangueil, 
      Toulouse.
FAU - Rouge, P
AU  - Rouge P
FAU - Albenque, J P
AU  - Albenque JP
FAU - Assoun, B
AU  - Assoun B
FAU - Massabuau, P
AU  - Massabuau P
FAU - Fauvel, J M
AU  - Fauvel JM
FAU - Bounhoure, J P
AU  - Bounhoure JP
FAU - Montastruc, J L
AU  - Montastruc JL
FAU - Montastruc, P
AU  - Montastruc P
LA  - fre
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Absence d'effet du monoxyde d'azote sur l'hypertension arterielle pulmonaire et 
      systemique induite par la defrenation sino-aortique.
PL  - France
TA  - Arch Mal Coeur Vaiss
JT  - Archives des maladies du coeur et des vaisseaux
JID - 0406011
RN  - 0 (Antihypertensive Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Carotid Sinus/physiopathology
MH  - Denervation
MH  - Dogs
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension/drug therapy/*physiopathology
MH  - Male
MH  - Nitric Oxide/*physiology/therapeutic use
MH  - Propranolol/pharmacology/therapeutic use
MH  - Vagotomy
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
PST - ppublish
SO  - Arch Mal Coeur Vaiss. 1995 Aug;88(8):1209-12.